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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۳، شماره ۳، صفحات ۲۱-۲۸
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عنوان انگلیسی Shark Cartilage Modulates Immune Responses in Stage III Breast Cancer Patients
چکیده انگلیسی مقاله Introduction: Shark cartilage has been shown to have some inhibitory effects on angiogenesis, metastasis, cell adhesion and proteolysis. Patients and Methods: In this study, we evaluated the effect of shark cartilage on immune response in three treatment session of 3 weeks, 6 weeks and 12 weeks on stage III invasive ductal carcinoma patients (n=15) compared to patients treated with a starch placebo (n=15). Results: The results indicated a significant increase after an initial 3 weeks treatment period in the level of IFNγ, but no significant decrease in the level of IL-4 before and after the treatment with shark cartilage. After 6 weeks, we noticed a significant increase (P< 0.05) in the level of IFNγ, but no significant increase in the level of IL-4 was observed after the treatment with shark cartilage. After 12 weeks, a significant increase in the level of IFNγ and a significant decrease in the level of IL-4 after the treatment with shark cartilage was observed; while there was no significant difference in the levels of both IFNγ and IL-4 at 3, 6 and 12 weeks treatment in the placebo group. We also evaluated the lymphocytes proliferation in pre and post treatments with shark cartilage or a placebo. Our findings showed a significant increase in lymphocyte proliferation in the three-week treatment. Conclusion: It is concluded that shark cartilage can stimulate immune response in a short period of time after treatment with it and modulate immune response in longer treatment duration toward Th1 cytokine pattern.
کلیدواژه‌های انگلیسی مقاله Breast cancer,IFNγ,IL-4,Shark cartilage
نویسندگان مقاله سمیه شاهرخی | somayeh shahrokhi
department of immunology, school of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

mh زهیر | mh zuhair
department of immunology, school of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

ma محققی | ma mohagheghi
cancer research center, cancer institute, faculty of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

t غضنفری | t ghazanfari
department of immunology, faculty of medicine, shahed university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

m ابتکار | m ebtekar
department of immunology, school of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/220
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