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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۳، شماره ۱، صفحات ۲۱-۲۶
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عنوان انگلیسی Predictive Factors of Survival Time after Hematopoietic Stem Cell Transplant in Acute Myeloid Leukemia Patients who Received Allogeneic BMT from Matched Sibling Donors Using Generalized Gamma Models
چکیده انگلیسی مقاله Introduction: This paper used Generalized Gamma (GG) distribution to find the predictive factors of overall survival (OS) after haematopoietic stem cell transplant (HSCT) in acute myeloid leukemia patients. Methods: Discrimination among the exponential, Weibull, GG, log-logistic, and lognormal distributions was done using maximum likelihood and Akaike information criteria. Results: The 5-year OS in 301 patients was 65% (95%CI: 60.7-69.3). Peak mortality hazard occurred at months 6-7 after HSCT then, it was U Shape. The data was fitted by GG distribution better than other distributions. Univariate analysis using GG distribution showed a positive association between OS with dose of infused WBC (P=0.018), CD3 (p=0.001), no relapse (P< 0.001), cGVHD (P< 0.001), and platelet recovery (P< 0.001). Multivariate analysis indicated that, OS has relationship with relapse (P< 0.001), platelet recovery (P=0.004), disease status at transplant (P=0.036) and aGVHD (P=0.036). Conclusion: We showed that GG distribution can be a useful tool for recognizing prognostic factors of OS in AML patients.
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نویسندگان مقاله کورش سایه میری | kourosh sayemiri
department of biostatistics, school of public health, tehran university of medical sciences, iran department of social medicine, school of medicine, ilam university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

mr اشراقیان | mr eshraghian
department of biostatistics, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کاظم محمد | kazem mohammad
department of biostatistics, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کامران علی مقدم | kamran alimoghaddam
epartment of nutrition and biochemistry, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a رحیمی فروشانی | a rahimi foroushani
department of biostatistics, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زراعتی | h zeraati
department of biostatistics, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمد رضا شمشیری | ahmad reza shamshiri
hematology- oncology and stem cell transplantation research center, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

k جعفریان | k djafarian
department of nutrition and biochemistry, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اردشیر قوام زاده | ardeshir ghavamzadeh
department of nutrition and biochemistry, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/203
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