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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲، شماره ۲، صفحات ۱۰-۱۵
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عنوان انگلیسی Mesenchymal Stem Cell Therapy for Multiple Sclerosis
چکیده انگلیسی مقاله Human mesenchymal stem cell (MSC) can be isolated from bone marrow (BM) and differentiated into multiple lineages. These properties make them promising tools in cell and gene therapy. Up to now, no definite therapeutic intervention for late stages of multiple sclerosis (MS) has been found. We decided to inject MS patients with autologous expanded MSC. Five patients participated in this ongoing study. Patients were injected intrathecally with the culture expanded BM MSCs. Patients were followed monthly for their clinical status and every 3 months re‌garding their magnetic resonance imaging. During 7 months follow up, one patient improved 1.5 EDSS, two patients improved by 1 and 2 scores, and two others remained unchanged till now. The first MRI findings of patients showed no change. We can claim that the injection of expanded MSC is a safe procedure. Three patients showed some de‌gree of improvement and the other two had no progression. Patients should be followed for at least one year and a larger sample is r quired in order to draw a definite conclusion.
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نویسندگان مقاله m محی الدین بناب | m mohyeddin bonab
hematology-oncology amp;amp; bmt research center


s یزدانبخش | s yazdanbakhsh
department of neurology, shariati hospital, tehran iran


k alimoghaddom | k alimoghaddom
hematology-oncology amp;amp; bmt research center


a قوام زاده | a ghavamzadeh
hematology-oncology amp;amp; bmt research center


f هوشمند | f hooshmand
3iranian ms society, tehran iran


j لطفی | j lotfi
iranian ms society, tehran iran


f طالبیان | f talebian
immunogenetics lab, department of immunology, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b نیک بین | b nikbin
immunogenetics lab, department of immunology, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/186
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