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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲، شماره ۱، صفحات ۱۳-۱۶
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عنوان انگلیسی Helicobacter Pylori Eradication can induce platelet recovery in chronic refractory idiopathic thrombocytopenic purpura
چکیده انگلیسی مقاله The prevalence of Helicobacter pylori infection and the effect of its eradication on platelet count in 95 Iranian patients with chronic refractory autoimmune thrombocytopenic purpura (CRITP) was investigated. 69 of 95 patients were infected with H.pylori (72.6%). H.pylori eradication was obtained in 69 infected CRITP pa‌tients who were not in remission and had platelet count below 100×109 at the time of infection assessment. 4 pa‌tients failed to eradicate of H.pylori. During follow-up (median 22.5 months). 3 of 33 of responsive patients re‌lapsed after 14 months of eradication. 30 of 65 H.pylori-eradicated patients (46%) showed a significant increase in platelet count accompanied by a significant decrease of platelet-associated immunoglobulin G (IgG). In forteen patients without H.pylori infection, platelet counts did not significantly increase with the same treatment. On the other hand, eradication therapy did not affect platelet counts in 6 patients with gastric ulcer. This re‌sponse was maintained in all responding patients throughout the follow up period. The assessment of H.pylori infection and its eradication shoud be attempted in CRITP as this approach could be an effective strategy, at least for some of these patients
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نویسندگان مقاله طالب آذرم | taleb azarm
professor in hematology and oncology ,esfahan university oh medical sciences saied-al shohada medical center, esfahan university of medical seienses; esfahan, islamic republic of iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

محمدعلی خامی | mohamadali khami
presedent of saied-al shohada medical center . esfahan .islamic republic of iran
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/176
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