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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱، شماره ۱، صفحات ۶-۱۱

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عنوان انگلیسی Acute Myeloid Leukemia (AML): The Role of Maintenance Chemo¬therapy
چکیده انگلیسی مقاله Maintenance treatment for patients with acute myeloid leukemia (AML) in remission has recently been controversially discussed and even abandoned by several groups. An analysis of 16 published multicenter trials, however, revealed the highest probabilities of relapse free survival (RFS) in the range of 35-42 % at 4-5 years only in patients assigned to maintenance treatment when adult age and intent-to-treat conditions were considered. After having demonstrated a superior RFS from 3 year maintenance following standard dose consolidation over that from consolidation alone (p< 0.0001), the German AMLCG requestioned the effect of maintenance randomly compared with sequential high-dose AraC and Mitoxantrone (S-HAM) in patients having received intensified induction treatment. The RFS shows an advantage for maintenance with 32 % versus 25 % (p= .021). We conclude that maintenance treatment continues to substantially contribute to the management of adult patients with AML, even as part of recent strategies using intensified induction treatment, and thus appears necessary in these settings.
کلیدواژه‌های انگلیسی مقاله Acute myeloid leukemia,maintenance therapy

نویسندگان مقاله |


ولفگنگ hiddemann | wolfgang hiddemann
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str. 33, d-48129 münster


ولفگنگ e berdel | wolfgang e berdel
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str. 33, d-48129 münster


برنارد wörmann | bernhard wörmann
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str. 33, d-48129 münster


helmut löffler | helmut löffler
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str. 33, d-48129 münster


claudia schoch | claudia schoch
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str. 33, d-48129 münster


torsten haferlach | torsten haferlach
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str. 33, d-48129 münster


ولف جان لوودویک | wolf dieter ludwig
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


گیورگ maschmeyer | georg maschmeyer
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


ایوا lengelder | eva lengelder
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


پیتر staib | peter staib
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


راینارد andreesen | reinhard andreesen
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


leopold balleisen | leopold balleisen
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


detlef haase | detlef haase
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


hartmut eimermacher | hartmut eimermacher
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


carlo aul | carlo aul
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


هربرت rasche | herbert rasche
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


jens uhlig | jens uhlig
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


آندراس grüneisen | andreas grüneisen
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


هانس ادگار رییس | hans edgar reis
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


joachim hartlapp | joachim hartlapp
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


ولف dietrich hirschmann | wolf dietrich hirschmann
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


هانس josef weh | hans josef weh
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


hermann josef pielken | hermann josef pielken
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


winfried gassmann | winfried gassmann
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


آندرآ schumacher | andrea schumacher
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


ماریا cristina sauerland | maria cristina sauerland
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster


achim heinecke | achim heinecke
university hospital, dept. of medicine, hematology and oncology, albert- schweitzer-str.33, d-48129 münster



نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/161
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