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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۳، صفحات ۲۲۲-۲۳۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Development of dry powder inhaler containing tadalafil-loaded PLGA nanoparticles
چکیده انگلیسی مقاله Inhalable dry powders containing poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were developed for the delivery of tadalafil (TAD) for treatment of life-treating pulmonary arterial hypertension. Taguchi design was employed to evaluate the effects of different formulation variables on the physicochemical characteristics of PLGA-NPs prepared using emulsion solvent evaporation method. Inhalable PLGA-NPs of TAD were successfully prepared by co-spray drying the PLGA-NPs with inert carriers. Physicochemical characteristics and in vitro deposition of the aerosolized drug were also evaluated. The optimized formulation was prepared using 7.5 mg of PLGA, 2.5 mg of TAD, sonication time of 6 min and 2% polyvinyl alcohol (PVA) as the stabilizer. The optimized aqueous/oil phase ratio for PLGA-NPs preparation was 10:1. Polymer/drug ratio was the most effective parameter on the release efficiency. Encapsulation efficiency, zeta potential and particle size of PLGA-NPs were more affected by aqueous/organic phase ratio. The spray dried powders containing PLGA-NPs had a mass median aerodynamic diameter (MMAD) in the range of 1.4–2.8 µm that was suitable for TAD delivery to the deep region of lung. The presence of L-leucine in mannitol containing formulations decreased the interparticulate forces between particles and increased significantly the process yield and fine particle fraction (FPF). The results indicated that prepared dry powders containing TAD-loaded PLGA-NPs were suitable for inhalation and has the potential for the treatment of pulmonary arterial hypertension.
کلیدواژه‌های انگلیسی مقاله Tadalafil,PLGA,Nanoparticles,Spray drying,Dry powder inhaler
نویسندگان مقاله ژاله ورشوساز | jaleh varshosaz
professor of pharmaceutics and biopharmaceutics editor-in-chief of research in pharmaceutical sciences department of pharmaceutics school of pharmacy and pharmaceutical sciences isfahan university of medical sciences isfahan iran tel 0098 - 313 792-7111 fax 0098 - 313 668 – 0011 e – mail emami@pharm.mui.ac.ir

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سمیه تیموری | somayeh taymouri
1department of pharmaceutics and novel drug delivery systems research centre, school of pharmacy, isfahan university of medical sciences, isfahan, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حامد همیشه کار | hamed hamishehkar
2drug applied research center, tabriz university of medical sciences, tabriz, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

راضیه وطن خواه | razieh vatankhah
1department of pharmaceutics and novel drug delivery systems research centre, school of pharmacy, isfahan university of medical sciences, isfahan, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شادی یعقوبی | shadi yaghubi
2drug applied research center, tabriz university of medical sciences, tabriz, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1764
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-402747.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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