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Medical Journal of Islamic Republic of Iran، جلد ۳۰، شماره ۱، صفحات ۶۴۷-۶۵۳
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عنوان انگلیسی Probiotics Lactobacillus plantarum and Bifidobacterium B94: cognitive function in demyelinated model
چکیده انگلیسی مقاله Background: Multiple Sclerosis (MS) is a disease of the immune system that creates damage of Learning and memory in that. Using probiotic supplements is recommended for preventing MS disease and improving memory. This study aimed to investigate the effect of Lactobacillus Plantarum (LP) and bifidobacterium B94 (BB94), on acquisition phase of spatial memory in the local demyelination of rats` hippocampus. Methods: In this study, 32 male Wistar rats were divided into control, damage group and treatment groups. Treatment groups were including (LP) and (BB94). After the induction of demyelination by 3 μl of EB into the right dentate gyrus of the hippocampus in treatment groups, 1.5×108 probiotic bacteria were administered by gavage for 28 days. Data was analyzed using one-way ANOVA and Tukey post-hoc tests (p≤0.05). Results: Findings demonstrated that injection of EB caused a significant increase in traveled distance (p< 0.01) and also escape latency (p< 0.05) compared with control group. Also, effect administrations of (LP) and (BB94) on traveled distance and escape latency were reviewed, and it was determined that administration of them do not cause significant reduction in the traveled distance compared with the lesion group. Also mentioned probiotics has no significant effect on swimming speed compared with lesion and saline groups. Conclusion: According to some studies, probiotics have a positive impact on improving the performance of spatial memory and learning, although the results of the current study could not indicate finality of this assumption. It seems that more researches is needed on this subject.
کلیدواژه‌های انگلیسی مقاله probiotic, demyelination, spatial memory, hippocampus.
نویسندگان مقاله مهدی گودرزوند | mahdi goudarzvand
department of pharmacology-physiology, school of medicine, alborz university of medical sciences, karaj, iran.


سمیرا رسولی کوهی | samira rasouli koohi
antimicrobial resistance research centre, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی البرز (Alborz university of medical sciences)

زهره خدایی | zohreh khodaii
dietary supplements and probiotic research center, alborz university of medical sciences, karaj, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سمیه سلیمان زاده مقدم | somayeh soleymanzadeh moghadam
antimicrobial resistance research centre, rasoul-e-akram hospital, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1021&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/18/article-18-407359.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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