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Iranian Journal of Public Health، جلد ۴۴، شماره ۱۰، صفحات ۱۳۵۹-۱۳۶۶
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عنوان انگلیسی Leishmania tropica in Stray Dogs in Southeast Iran
چکیده انگلیسی مقاله Background: Cutaneous leishmaniasis (CL) caused by Leishmania tropica is endemic in Kerman, southeastern Iran. While dogs have long been implicated as the main domestic reservoirs of L. infantum , etiological agent of zoonotic visceral leishmaniasis (ZVL), they can also carry L. tropica infection. The objective of the present study was to determine molecular identity and to evaluate histopathological changes due to CL in dogs in a well-known focus of anthroponotic CL (ACL) in Kerman, southeastern Iran. Methods: This study was carried out in three prospective series from 1994 to 2013 on dogs. Tissue samples were taken from 471 stray dogs. Pathological specimens including skin, spleen, liver and lymph nodes were prepared for paraffin blocks, sectioning and staining for further histopathological examination. PCR amplification of kDNA was performed to identify the causative agent and sequencing. Overall, two out of 471 stray dogs were infected with L. tropica . Hyperplasia of red pulp by the proliferation of histiocytes, lymphocytes, plasma cells and cytoplasm of histiocytes collection of amastigotes was noted. Results: Based on the results of PCR products and sequencing analysis, the parasites isolated from the lesions of two dogs were characterized as L. tropica , corresponding to a band of 830 bp Conclusion: This finding revealed infection with L. tropica in stray dogs in the city and suburbs of Kerman. This information is essential for public health concerns and planning effective future control programs. The role of dogs as potentional reservoir in the epidemiology of ACL needs further investigation.
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نویسندگان مقاله مهدی بامروت | mehdi bamorovat


ایرج شریفی | iraj sharifi


شهریار دبیری | shahriar dabiri


محمد علی محمد مهدی | mohammad ali moham madi


مجید فصیحی هرندی | majid fasihi harandi


مهدی محبعلی | mehdi mohebali


محمد رضا افلاطون یان | mohammad reza aflatoon ian


علیرضا کیهانی | alireza keyhani


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/5000
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