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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۱، شماره ۳، صفحات ۲۰۹-۲۱۶
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی High Prevalence of Vitamin D Deficiency in Newly Diagnosed Acute Myeloid Leukemia Patients and Its Adverse Outcome
چکیده انگلیسی مقاله Background: Although several studies have supported a preventive and therapeutic role of vitamin D (Vit D) for different types of cancers, we face insufficient documentation in acute myeloid leukemia (AML). So, we examined whether the serum calcidiol (25(OH)D) levels at the time of induction therapy have any impact on response and relapse in AML patients. Subjects and Methods: Blood samples were collected from 65 patients on days 0 and 28 th of treatment to evaluate serum concentration of 25(OH)D and its effects on complete remission (CR) achievement, relapse rate and hospitalization length. Results: Of the 65 patients who were included in the study, 38 were male (58.5%) and 27 were female (41.5%). Median age at the time of treatment was 37 years (range 15-68). 6% of the participants were older than 60 years. In regard to 25(OH)D levels, 81.5% of AML patients were deficient (levels < 20 ng/ml). There was a significant difference in CR between patients with sufficient and deficient level of 25(OH)D. Deficient patients had longer length of hospitalization than those with sufficient levels. Also Vitamin D deficient patients had higher serum ALP levels. The mean level of 25(OH)D on treatment day 28 th in our study was significantly lower than the baseline value. Conclusion: The results of the study showed that serum 25(OH)D levels deficiency was highly prevalent among Iranian AML patients. Furthermore, higher Vit D levels in AML patients were associated with better outcome in these patients.
کلیدواژه‌های انگلیسی مقاله Acute myeloid leukemia (AML), Vitamin D, Remission, Relapse
نویسندگان مقاله فاطره سید علیپور | fatere seyedalipour
research center for rational use of drugs, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آوا منصوری | ava mansouri
hematology-oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد واعظی | mohammad vaezi
clinical pharmacy department, faculty of pharmacy, tehran university of medical sciences, tehran, iran research center for rational use of drugs, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

خیراله غلامی | kheirollah gholami
clinical pharmacy department, faculty of pharmacy, tehran university of medical sciences, tehran, iran research center for rational use of drugs, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ملوک حاجی بابایی | molouk hadjibabaie
hematology-oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اردشیر قوام زاده | ardeshir ghavamzadeh


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/705
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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