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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۱، شماره ۱، صفحات ۵۸-۶۲
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عنوان انگلیسی Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia: Results from a Single Center, 1993-2011
چکیده انگلیسی مقاله Background: For adult ALL patients, the indications and appropriate timing of allogeneic hematopoietic stem cell transplantation (AHSCT) continue to be debated. The primary aim of this single-institution study was to compare the results of our adult ALL patients that had been allografted with those reported in the current literature. Subjects and Methods: This study included 53 consecutive adults with acute lymphoblastic leukemia (ALL) who underwent allogeneic hematopoietic stem cell transplantation (AHSCT) with myeloablative (92%) and reduced-intensity (8%) conditioning between 1993 and 2011. Results: Mean patient age was 27 years (SD:8.62) and donor age was 33.7 years (SD:9.47). Fourteen patients were in first remission; 21 in ≥2nd remission, 15 in relapse and 3 had primary refractory leukemia. Thirty-four, 15 and 4 patients received busulfan plus cyclophosphamide, cyclophosphamide/total body irradiation and fludarabine-based regimens, respectively. For graft-versus-host disease (GVHD) prophylaxis, cyclosporine plus methotrexate were used. Forty-six donors were related and 7 were unrelated. Thirty patients received granulocyte-colony stimulating factor (G-CSF) mobilized peripheral blood and 23 received bone marrow as stem cell source. Twenty-six patients relapsed at a mean duration of 11.3 months (SD:19.1). Forty-four patients succumbed to their disease after a mean follow-up of 13.6 months (SD:19.5). The cause of mortality was relapse (n=24; 54.5%) and transplant-related etiologies (n=20; 45.5%). The estimated five year probabilities of overall survival (OS) and progression-free survival (PFS) were 37% and 12%, respectively. Conclusion: By multivariate analyses, transplantation in first remission was the most important predictor of transplant success.
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نویسندگان مقاله ipek yonal hindilerden | ipek yonal hindilerden
department of internal medicine, division of hematology, istanbul university istanbul medical faculty, istanbul, turkey


sevgi kalayoglu besisik | sevgi kalayoglu besisik
department of internal medicine, division of hematology, istanbul university istanbul medical faculty, istanbul, turkey


nuray gurses koc | nuray gurses koc
hematology clinic, istanbul bakırkoy sadi konuk training and research hospital, istanbul, turkey


fehmi hindilerden | fehmi hindilerden
department of internal medicine, division of hematology, istanbul medipol university, istanbul, turkey


دنیز sargin | deniz sargin


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/559
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