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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۳، صفحات ۳۳۰-۳۳۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents
چکیده انگلیسی مقاله Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials and Methods:Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out. Results: Discs showed excellent mucoadhesion and released high amount of the active ingredients (47%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity. Conclusion:This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn’t follow the fick’s law. The water uptake and dissolution (DS), increased with the passing of time.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله شکوه سادات حامدی | shokouhsadat hamedi
department of traditional pharmacy, faculty of traditional medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا شمس اردکانی | mohammad reza shams ardakani
department of pharmacognosy, school of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

امید صادق پور | omid sadeghpour
herbal medicine department, research institute for islamic and complementary medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

غلامرضا امین | gholamreza amin
department of pharmacognosy, school of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

داود حاجی قاسمعلی | dawood hajighasemali
faculty of traditional medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

حسین عرفایی | hossein orafai
department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_6653.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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