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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۲، صفحات ۲۱۵-۲۲۰
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چکیده فارسی مقاله
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عنوان انگلیسی Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules
چکیده انگلیسی مقاله Objective(s): The aim of this study was to determine the important molecules involved in apoptosis induction by opium in Jurkat cell line. Materials and Methods: Jurkat cells were incubated 48 hrs with2.86×10-5 g/ml concentration of opium and apoptosis as well as expression levels of related molecules weremeasured. Results: Our results demonstrated that 50.3±0.2 percent of opium treated Jurkat cells were revealed apoptotic features. The levels of mRNA of several pro-apoptotic and anti-apoptotic molecules were increased and decreased, respectively, in the opium treated cells. The results also demonstrated that expression levels of BCL2, DFFA and NOL3 as anti-apoptotic molecules were increased in the opium treated cells. Conclusion: It seems that opium induces apoptosis in Jurkat cells via both intrinsic and extrinsic pathways. Although opium induces apoptosis in the cells but increased expression of some anti-apoptotic molecules may be a normal resistance of the cell for death.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Jurkat cells, PCR array
نویسندگان مقاله محمد کاظمی عرب آبادی | mohammad kazemi arababadi
department of laboratoty sciences, faculty of paramedicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

غلامرضا اسدی کرم | gholamreza asadikaram
endocrinology and metabolism research center, institute of basic and clinical physiology sciences and department of biochemistry, school of medicine, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_6548.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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