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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۶، صفحات ۴۵۴-۴۵۹
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عنوان انگلیسی Mild hypothermia reduces expression of Fas/FasL and MMP-3 after cerebral ischemia-reperfusion in rats
چکیده انگلیسی مقاله Objective(s):To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Materials and Methods:Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Mild hypothermia (33±0.5℃) for 6 hr was initiated at the start of reperfusion. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3. Results: Infarct volume was reduced in the hypothermia group (18.43±4.23%) compared with the normothermia group (24.76±5.76%) (P< 0.05). In mild hypothermia group, numbers of Fas-positive and MMP-3 positive cells were significantly less than those of normothermia group (P< 0.05). Neurological functional scores of mild hypothermia were significantly improved (P< 0.05). Conclusion: Mild hypothermia decreases infarct volume after cerebral ischemia-reperfusion, reduces Fas and MMP-3 expression, but increases FasL in cerebral ischemia-reperfusion rats.
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نویسندگان مقاله jingkun zhao | jingkun zhao
department of neurology, the first affiliated hospital of harbin medical university, harbin, heilongjiang, china


shurong duan | shurong duan
department of neurology, the first affiliated hospital of harbin medical university, harbin, heilongjiang, china


jinxia zhou | jinxia zhou
puren hospital of wuhan, wu han, china


ruihong سون | ruihong sun
department of neurology, the first affiliated hospital of harbin medical university, harbin, heilongjiang, china


لیمینگ زانگ | liming zhang
department of neurology, the first affiliated hospital of harbin medical university, harbin, heilongjiang, china


desheng ونگ | desheng wang
department of neurology, the first affiliated hospital of harbin medical university, harbin, heilongjiang, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_2931.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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