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Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۸، صفحات ۸۹۶-۹۰۰
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عنوان انگلیسی Effect of Methylsulfonylmethane Pretreatment on Aceta-minophen Induced Hepatotoxicity in Rats
چکیده انگلیسی مقاله Objective(s): Methylsulfonylmethane (MSM) is a sulfur-containing compound found in a wide range of human foods including fruits, vegetables, grains and beverages. In this study the effect of MSM pretreatment on acetaminophen induced liver damage was investigated. Materials and Methods: Male Sprague Dawley rats were pretreated with 100 mg/kg MSM for one week. On day seven rats were received acetaminophen (850 mg/kg, intraperitoneal). Twenty-four hours later, blood samples were taken to determine serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Tissue samples of liver were also taken for the determination of the levels of malondialdehyde (MDA); total glutathione (GSH), superoxide dismutase (SOD), and myeloperoxidase (MPO) activity together with histopathological observations. Results:High dose of acetaminophen administration caused a significant decrease in the GSH level of the liver tissue, which was accompanied with a decrease in SOD activity and increases in tissue MDA level and MPO activity. Serum ALT, AST levels were also found elevated in the acetaminophen-treated group. Pretreatment with MSM for one week was significantly attenuated all of these biochemical indices. Conclusion: Our findings suggest that MSM pretreatment could alleviate hepatic injury induced by acetaminophen intoxication, may be through its sulfur donating and antioxidant effects.
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نویسندگان مقاله شهاب بهلولی | shahab bohlooli
department of pharmacology, school of medicine, ardabil university of medical sciences, ardabil, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اردبیل (Ardabil university of medical sciences)

سعدالله محمدی | sadollah mohammadi
department of pharmacology, school of medicine, ardabil university of medical sciences, ardabil, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اردبیل (Ardabil university of medical sciences)

کیوان امیرشاهرخی | keyvan amirshahrokhi
department of pharmacology, school of medicine, ardabil university of medical sciences, ardabil, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اردبیل (Ardabil university of medical sciences)

حافظ میرزانژاد اصل | hafez mirzanejad asl
department of pharmacology, school of medicine, ardabil university of medical sciences, ardabil, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اردبیل (Ardabil university of medical sciences)

محمد یوسفی | mohammad yosefi
department of pharmacology, school of medicine, ardabil university of medical sciences, ardabil, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اردبیل (Ardabil university of medical sciences)

امیر محمدی nei | amir mohammadi nei
department of pharmacology, school of medicine, ardabil university of medical sciences, ardabil, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اردبیل (Ardabil university of medical sciences)

میر مهدی چینی فروش | mir mehdi chinifroush
department of pathology, school of medicine, ardabil university of medical sciences, ardabil, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اردبیل (Ardabil university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_1346.html
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