این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۳، شماره ۵۹، صفحات ۱۱۱-۱۲۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Phytochemical and Antioxidant Activities of Berberis integerrima and Berberis vulgaris and Pharmacological Effects of the more Active Species on Alloxan-Induced Diabetic Rats
چکیده انگلیسی مقاله Background: Medicinal plants with biologically active components such as antioxidant and antidiabetic are useful sources of novel therapeutics. In Iran, traditionally believed that the aqueous extract of berberry fruit (Berberis integerima F.) improved health, especially in people with diabetes. Objective: In this study, in vitro phytochemical and antioxidant activities of B. integerrima and B. vulgaris fruit aqueous extracts (BIFA and BVFA) were compared. Effects of more active species on fasting blood sugar (FBS), serum lipid, and malondialdehyde (MDA) were evaluated in alloxan-induced diabetic rats. Methods: The phytochemical potential and antioxidant activity of these extracts were quantified in terms of total phenolic content and total reducing power, respectively. BIFA (500 mg/kg) and glibenclamide (2 mg/kg) were administered orally to alloxan-induced diabetic rats and FBS, body weight, lipid profile, and serum MDA were monitored at 0, 7, 14, and 21 days after induction of diabetes. Results: BIFA showed the highest phenolic content (6.816 ± 0.132 mg/g of dry extract) and antioxidant activity (0.134 ± 0.022 EC50 mg/mL). LD50 of BIFA was found to be ˃2500 mg/kg. FBS, lipid profile, and serum MDA have been significantly reduced in BIFA-treated rats after 21 days versus diabetic control and glibenclamide-treated rats. Extract has significantly decreased FBS levels of rats from 138.1 ± 1.68 to 82.00 ± 4.02 mg/dL. Furthermore, body weight has significantly improved in treated groups. Conclusion: The results indicate B. integerrima with high phytochemical and antioxidant activities, has the potential of suppressed hyperglycemia, hyperlipidemia and lipid peroxidation.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله m بیانی | m bayani
faculty of veterinary medicine, semnan university, semnan, iran

سازمان اصلی تایید شده: دانشگاه سمنان (Semnan university)

m احمدی همدانی | m ahmadi hamedani
department of clinical sciences, faculty of veterinary medicine, semnan university, semnan, iran tel 98-911-3716709

سازمان اصلی تایید شده: دانشگاه سمنان (Semnan university)

a جبلی جوان | a jebelli javan
department of food hygiene, faculty of veterinary medicine, semnan university, semnan, iran

سازمان اصلی تایید شده: دانشگاه سمنان (Semnan university)

نشانی اینترنتی http://www.jmp.ir/browse.php?a_code=A-10-958-4&slc_lang=en&sid=fa
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 1
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات