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Iranian Journal of Microbiology، جلد ۶، شماره ۶، صفحات ۳۸۷-۳۹۱
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عنوان انگلیسی Choosing the correct empirical antibiotic for urinary tract infection in pediatric: Surveillance of antimicrobial susceptibility pattern of Escherichia coli by E-Test method.
چکیده انگلیسی مقاله Background and Objectives: Urinary Tract Infections (UTIs) are of the most common bacterial diseases worldwide. We investigate the antibiotic susceptibility patterns of Escherichia coli (E. coli) strains isolated from pediatric patients with community acquired urinary tract infection (UTI) to find a clinical guidance for choosing a right empirical antibiotic in these patients. Materials and Methods: In this cross sectional study, 100 urine specimens which were positive for E. coli had been investigated for antibiotics susceptibility pattern. The susceptibility to Co-trimoxazol (25µg), Amikacin (30µg), Ceftriaxone (30µg), Nalidixic Acid (30µg), Cefixime (5µg), and Nitrofurantoin (300µg) tested with Disk diffusion agar and MIC determined with the E-test. Results: Mean age of patients was 38 Months. Girls had greater proportion than boys (74 versus 26%). In Disk diffusion method, 26% of the isolates were susceptible to cotrimoxazole. Susceptibility to amikacin, ceftriaxone, nitrofurantoin, nalidixic acid and cefixime was 94%, 66%, 97%, 62% and 52%, respectively. By E-Test method and according to CLSI criteria susceptibility for co-trimoxazol, amikacin, ceftriaxone and nalidixic acid was 37%, 97%, 67% and 50%, respectively. The highest percentage of agreement between Disk diffusion and E-Test method was found for amikacin (96%) and the lowest percentage for co-trimoxazole (89%). Conclusions: Treatment failure, prolonged or repeated hospitalization, increased costs of care, and increased mortality are some consequence of bacterial resistance in UTIs. Misuse of antibiotics in each geographic location directly affects antibiotic resistance pattern. In the treatment of UTI, proper selection of antimicrobial agents should be relevant to the bacterial susceptibility testing surveillance. According to our results, amikacin as an injectable drug and nitrofurantoin as an oral agent could be used as a drug of choice in our region for children with UTIs.
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نویسندگان مقاله ایرج صدیقی | iraj sedighi
department of pediatrics, school of medicine, hamadan university of medical sciences, hamadan, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

عباس سلگی | abbas solgi
department of pediatrics, school of medicine, hamadan university of medical sciences, hamadan, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

علی امانتی | ali amanati
pediatric infections research center, shahid beheshti university of medical sciences, tehran, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

محمد یوسف علیخانی | mohammadyousef alikhani
brucellosis research center, hamadan university of medical sciences, hamadan, iran and department of microbiology, school of medicine, hamadan university of medical sciences, hamadan, ir iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/367
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