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Medical Journal of Islamic Republic of Iran، جلد ۲۷، شماره ۲، صفحات ۵۷-۶۱
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عنوان انگلیسی Effect of Zafirlukast on improving lung function in patients with chronic obstructive pulmonary diseases
چکیده انگلیسی مقاله Background : There is little evidence about the role of Zafirlukast (a highly selective LTD4 antagonist) in Chronic Obstructive Pulmonary Disease (COPD). The Zafirlukast can reduce the need for short-acting rescue β2 agonists, produce fewer exacerbations of asthma and increased quality of life as possible benefits treatment for asthma. The aim of our study was to evaluate the effects of Zafirlukast improvement of lung function in patients with COPD. Methods: Twenty five patients with moderate to severe COPD, in stable phase of the disease, participated in this interventional, quasi-experimental study. All patients were received 40 mg oral Zafirlukast per day for 2 weeks. Pulmonary function Test was performed both at the baseline and at the end of the study. Data were analyzed with paired t-test using SPSS v.16. Results: The mean age of the patients was 67.29 (SD=5.56) years with the mean baseline for forced expiratory volume in first second (FEV1) equal to 41.79% (SD=14.96) of predicted value. After 2 weeks, the mean improvements in forced vital capacity (FVC), FEV1 and FEV1/FVC were 4.75% (SD=13.18), 3.71% (SD=9.19) and 9.33(SD=27.08), respectively. Zafirlukast produced a non-significant (p>0.05) bronchodilation, with maximum mean increase in FEV1 of 0.04 lit (3%) above baseline. Conclusion: Results showed that Zafirlukast has no considerable bronchodilatory effect in COPD. Present study consisted of a very short treatment period and it is possible that the extension of this period could possibly have more effects. Additional larger studies are needed to verify the impact of leukoterien receptor antagonists on improving the lung function in COPD patients.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سید علی جواد موسوی | seyed ali javad moosavi
pulmonologist, rasoul-e-akram hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Rasoul-e-Akram Hospital,

هانیه راجی | hanieh raji
department of internal medicine, faculty of medicine, jundishapur university of medical sciences, ahvaz, iran.


بهارک تاثریان | baharak tasorian
tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

الیاس مصطفی پور | elyas mostafapour
student scientific research committee, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهاب شهابی | shahab shahabi
isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد purfakharan | mohammad purfakharan
, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید محمد فرشته نژاد | seyed mohammad fereshtehnejad
firoozgar clinical research development center fcrdc , tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Firoozgar Clinical Research Development Center (FCRDC),

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-572&slc_lang=en&sid=en
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