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Iranian Journal of Otorhinolaryngology، جلد ۲۹، شماره ۶، صفحات ۳۴۱-۳۴۶
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عنوان انگلیسی Methylprednisolone Versus Dexamethasone for Control of Vertigo in Patients with Definite Meniere's Disease: A Randomized Clinical Trial
چکیده انگلیسی مقاله Introduction: Definite Meniere's diseaseis associated with two or more definitive periods of vertigo along with hearing loss, plus tinnitus or aural fullness or both. This study aimed to compare the effect of intratympanic dexamethasone and methylprednisolone on the functional-level scale of pure-tone audiometry (PTA), and class outcome measures of vertigo.  Materials and Methods: In this clinical study, 69 patients with definite Meniere's disease, referred to the tertiary otolaryngology center, were randomly assigned to two groups: 36 patients were treated with intratympanic dexamethasone (4mg/dl) and 33 patients were treated with intratympanic methylprednisolone (40mg/dl). Each group received three weekly injections. After a follow-up of 1 and 6 months, PTA changes and vertigo control were evaluated.  Results: There was no statistically significant difference between the two groups with regard to control of vertigo (P=0.866, P=0.879 for 1 and 6 months post injection, respectively). PTA improvement was statistically significantly higher in the methylprednisolone group (P=0.006).  Conclusion: In summary, intratympanic corticosteroid is an effective treatment for Meniere's disease and can prevent other invasive treatments. Intratympanic methylprednisolone can improve hearing level to a greater extent than intratympanic dexamethasone, but the two groups were similarly beneficial in controlling vertigo. However, there was a trend toward a more sustained benefit with methylprednisolone.
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نویسندگان مقاله الهام معصومی | elham masoumi
otorhinolaryngology research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ساسان دبیری | sasan dabiri
otorhinolaryngology research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد تقی خورسندی آشتیانی | mohammad taghi khorsandi ashtiani
otorhinolaryngology research center, tehran university of medical siences, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

رضا عرفانیان | reza erfanian
otorhinolaryngology research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سعید سهراب پور | saeed sohrabpour
otorhinolaryngology research center, tehran university of medical sciences, tehran , iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نسرین یزدانی | nasrin yazdani
otorhinolaryngology research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علیرضا صفایی | alireza safaee
otorhinolaryngology research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا فیروزی فر | mohammadreza firouzifar
otorhinolaryngology research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijorl.mums.ac.ir/article_9571.html
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