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Avicenna Journal of Phytomedicine، جلد ۷، شماره ۶، صفحات ۴۹۵-۵۰۱
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عنوان انگلیسی Effects of Musa sapientum stem extract on experimental models of anxiety
چکیده انگلیسی مقاله Objective: The Musa sapientum (banana) plant extract has shown antioxidant activity in previous studies. Oxidative stress is one of the important factors implicated in the pathogenesis of anxiety disorders. The present study aimed to evaluate the anxiolytic activity of aqueous extract of M. sapientum stem (MSSE) in experimental models in mice. Material and Methods: Elevated Plus Maze method and locomotor monitoring by photoactometer were used. Animals were divided into five different groups (n=6/group). The vehicle, standard and the experimental groups were given distilled water (10 ml/kg), diazepam (1 mg /kg intraperitoneally) and incremental doses of 25, 50 and 100 mg/kg of MSSE, respectively, prior to the experiment. The standard group received diazepam. Results: The number of open arm entries and the duration of time spent in the open arms in the MSSE-treated groups increased significantly in a dose-dependent manner as compared to that of control group. The duration of time spent in closed arms in the MSSE-treated groups decreased significantly in a dose-dependent manner as compared to that of the control group. MSSE also decreased the locomotor activity significantly at all three test doses. Conclusion: The results of this study suggest an anxiolytic activity for MSSE, which make it a potential natural compound for treatment of anxiety disorders.
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نویسندگان مقاله الف jielella reddy | aditya jielella reddy
department of pharmacology, sms amp;r, sharda university, gr. noida, ncr, india


ashok کومار dubey | ashok kumar dubey
department of pharmacology, sms amp;r, sharda university, gr. noida, ncr, india


shailendra handu | shailendra handu
department of pharmacology, sms amp;r, sharda university, gr. noida, ncr, india


sachin manocha | sachin manocha
department of pharmacology, sms amp;r, sharda university, gr. noida, ncr, india


pramod kumari mediratta | pramod kumari mediratta
department of pharmacology, sms amp;r, sharda university, gr. noida, ncr, india


قاضی احمد mushtaq | qazi ahmed mushtaq
department of pharmacology, sms amp;r, sharda university, gr. noida, ncr, india
نشانی اینترنتی http://ajp.mums.ac.ir/article_8822.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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