این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Pediatrics، جلد ۵، شماره ۹، صفحات ۵۶۸۷-۵۶۹۱
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عنوان انگلیسی Combined Therapy for Anti-N-methyl D-aspartate Receptor Encephalitis
چکیده انگلیسی مقاله Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained psychiatric symptoms and rapidly lost consciousness. CT scan revealed mediastinal teratoma and serum/spinal fluid was positive for anti-NMDAR antibody. He kept comatose and his brain stem function was profoundly disturbed. His symptoms were refractory to first-line therapy, which involved tumor resection, methylprednisolone (mPSL) pulse, Intravenous immunoglobulin (IVIG), and plasma exchange. We administered a combination therapy of rituximab and cyclophosphamide as second-line therapy and achieved complete recovery without adverse effects related to treatment. Conclusion  We consider early intensive treatment with a combination of rituximab and cyclophosphamide to be a safe and effective option for severe cases of anti-NMDAR encephalitis.
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نویسندگان مقاله takahiro kido | takahiro kido
department of pediatrics, university of tsukuba hospital, ibaraki, japan, and department of emergency and critical care medicine, university of tsukuba hospital, ibaraki, japan.


chie کبایاشی | chie kobayashi
department of child health, faculty of medicine, university of tsukuba, ibaraki, japan.


tatsuyuki ohto | tatsuyuki ohto
department of child health, faculty of medicine, university of tsukuba, ibaraki, japan.


yukitoshi takahashi | yukitoshi takahashi
national epilepsy center, shizuoka institute of epilepsy and neurological disorders, nho, shizuoka, japan.


ryo sumazaki | ryo sumazaki
department of child health, faculty of medicine, university of tsukuba, ibaraki, japan.


takashi fukushima | takashi fukushima
department of child health, faculty of medicine, university of tsukuba, ibaraki, japan.
نشانی اینترنتی http://ijp.mums.ac.ir/article_9035.html
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