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International Journal of Pediatrics، جلد ۵، شماره ۶، صفحات ۵۲۰۳-۵۲۱۰
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عنوان انگلیسی The Relationship of Vitamin D and Calcium level with Preeclampsia Severity: A Case- control Study
چکیده انگلیسی مقاله Background Vitamin D deficiency is associated with physiologic changes that are similar to pathogenesis of preeclampsia. Although association of vitamin D and preeclampsia has been studied previously, their results are not consistent. The aim of this study was to investigate the relationship of serum vitamin D and calcium with preeclampsia severity. Materials and Methods: This case- control study was conducted in 75 healthy pregnant women and 74 pregnant women with preeclampsia (46 mild preeclampsia and 28 severe preeclampsia) in Qazvin, Iran in 2015. Serum vitamin D, calcium, and albumin were measured; corrected calcium was also calculated. Hypocalcemia and vitamin D deficiency were compared between the groups. Logistic regression analysis was used to study the independent association of hypocalcemia and hypovitaminosis D with preeclampsia. Results Mean serum vitamin D level was 27.7±15.3, 22.9±15.9, and 27.6±16.6 in normal, mild preeclampsia, and severe preeclampsia groups (P> 0.05); also vitamin D deficiency was not different between the groups. Hypocalcemia in severe preeclampsia group was more frequent than normal group (25.9% vs. 6.6%, P: 0.017). Hypocalcemia was associated with severe preeclampsia after adjustment for age, parity, and calcium supplement consumption (OR: 6.7, 95% CI: 1.45-30.79; P: 0.015). Conclusion There was not any association between vitamin D deficiency and preeclampsia in the present study, however low corrected serum calcium was associated with about six times increased risk of sever preeclampsia. More studies are needed to determine the role of hypocalcemia and vitamin D in preeclampsia.
کلیدواژه‌های انگلیسی مقاله Hypocalcemia, pre-eclampsia, pregnancy, Vitamin D deficiency
نویسندگان مقاله سیما هاشمی پور | sima hashemipour
associate professor of endocrinology, metabolic diseases research center, qazvin university of medical sciences, qazvin, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

ندا اسماعیل زاده ها | neda esmailzadehha
general practitioner, metabolic diseases research center, qazvin university of medical sciences, qazvin, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

امیر ضیایی | amir ziaee
professor of endocrinology, pediatric growth and development research center, institute of endocrinology and metabolism, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محمد حسین خوینی ها | mohammad hossein khoeiniha
pathologist, metabolic diseases research center, qazvin university of medical sciences, qazvin, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

الهام darvishgoftar | elham darvishgoftar
assistant of gynecology and obstetrics, metabolic diseases research center, qazvin university of medical sciences, qazvin, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

زهرا مسگری | zahra mesgari
assistant of gynecology and obstetrics, metabolic diseases research center, qazvin university of medical sciences, qazvin, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

فاطمه پاشازاده | fatemeh pashazade
instructor of nursing, school of nursing and midwifery, qazvin university of medical sciences, qazvin, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

شکوه السادات ابوترابی | shokohossadat abotorabi
assistant professor of gynecology and obstetrics, metabolic diseases research center, qazvin university of medical sciences, qazvin, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

نشانی اینترنتی http://ijp.mums.ac.ir/article_8181.html
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