این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Blood and Cancer، جلد ۵، شماره ۱، صفحات ۱۹-۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Medium and High-Dose Methotrexate-Induced Toxicity in Children with Acute Lymphoblastic Leukemia
چکیده انگلیسی مقاله Background: Methotrexate has an important role in treatment of acute leukemia. We measured methotrexate level in CSF and blood of children with acute lymphoblastic leukemia to determine complications and outcomes. Materials and Methods: One hundred and twenty patients (73 male, 47 female), with mean age at diagnosis of 6.1 years (11mo_15years) entered the study. Patients were divided into two groups receiving consolidation therapy of medium-dose MTX 2g/m2/24hrs, or high- dose MTX 5g/m2/24hrs respectively. Clinical features, concentration and pharmacokinetic parameters of MTX, as well as serum creatinine were assessed. Results: The mean serum MTX levels (24 hours after therapy) was 8.9_ 9.8 µmol/L after 4 courses. The mean serum MTX level 48 hours after therapy was 0.3-0.42 µmol/L after 4 courses. The mean CSF MTX levels after therapy was 0.22 µmol/L. The mean serum creatinine before and after MTX therapy were not different between two groups. Mucositis was observed as grade 0 in 65.8%, grade 1 in 15%, grade 2in 15%, grade 3 in 3.3% and grade 4 in 0.8% of patients. CNS relapse was observed in 20.8% patients. The mean MTX level after 24 hours in patients with CNS relapse were lower than the mean MTX level in patients with no CNS relapse. Mortality in patients with severe mucositis was higher than patients with mild mucositis (P value
کلیدواژه‌های انگلیسی مقاله Leukemia, treatment, side effect, methotrexate
نویسندگان مقاله | r zangooei
mahak children’s hospital


a هدایتی اصل | a hedayati asl
mahak children’s hospital


p وثوق | p vossough
mahak children’s hospital


a مهرور | a mehrvar
mahak children’s hospital


mr گلپایگانی | mr golpayegani


f یزدی | f yazdi
mahak children’s hospital

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

f عزیززاده | f azizzade


m آل بویه | m alebouyeh
mahak children’s hospital

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

m فرانوش | m faranoush
mahak children’s hospital
نشانی اینترنتی http://www.ijbc.ir/browse.php?a_code=A-10-1-30&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 1
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات