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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱۲، صفحات ۱۳۶۰-۱۳۶۷
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عنوان انگلیسی Vitamin E improved bone strength and bone minerals in male rats given alcohol
چکیده انگلیسی مقاله Objective(s): Alcohol consumption induces oxidative stress on bone, which in turn increases the risk of osteoporosis. This study determined the effects of vitamin E on bone strength and bone mineral content in alcohol-induced osteoporotic rats. Materials and Methods: Three months old Sprague Dawley male rats were randomly divided into 5 groups: (I) control group; (II) alcohol (3 g/kg) + normal saline; (III) alcohol (3 g/kg) + olive oil; (IV) alcohol (3 g/kg) + alpha-tocopherol (60 mg/kg) and (V) alcohol (3 g/kg) + palm vitamin E (60 mg/kg). The treatment lasted for three months. Following sacrifice, the right tibia was subjected to bone biomechanical test while the lumbar (fourth and fifth lumbar) and left tibia bones were harvested for bone mineral measurement. Results: Alcohol caused reduction in bone biomechanical parameters (maximum force, ultimate stress, yield stress and Young's modulus) and bone minerals (bone calcium and magnesium) compared to control group (P< 0.05). Palm vitamin E was able to improve bone biomechanical parameters by increasing the maximum force, ultimate stress and Young's modulus (P< 0.05) while alpha-tocopherol was not able to. Both alpha-tocopherol and palm vitamin E were able to significantly increase tibia calcium and magnesium content while only alpha-tocopherol caused significant increase in lumbar calcium content (P< 0.05). Conclusion: Both palm vitamin E and alpha-tocopherol improved bone mineral content which was reduced by alcohol. However, only palm vitamin E was able to improve bone strength in alcohol treated rats.
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نویسندگان مقاله syuhada ذکریا | syuhada zakaria
department of pharmacology, faculty of medicine, universiti kebangsaan malaysia medical centre, kuala lumpur, malaysia


siti zulaikha mat حسین | siti zulaikha mat husain
department of pharmacology, faculty of medicine, universiti kebangsaan malaysia medical centre, kuala lumpur, malaysia


kong ying hwey | kong ying hwey
department of pharmacology, faculty of medicine, universiti kebangsaan malaysia medical centre, kuala lumpur, malaysia


kek xin کیا | kek xin kai
department of pharmacology, faculty of medicine, universiti kebangsaan malaysia medical centre, kuala lumpur, malaysia


عبدالله محمد badawi | abdullah mohd badawi
department of pharmacology, faculty of medicine, universiti kebangsaan malaysia medical centre, kuala lumpur, malaysia


nurul amiza عبد غنی | nurul amiza abd ghani
department of pharmacology, faculty of medicine, universiti kebangsaan malaysia medical centre, kuala lumpur, malaysia


محمد عریضی عزیز | muhamad arizi aziz
department of pharmacology, faculty of medicine, universiti kebangsaan malaysia medical centre, kuala lumpur, malaysia


محمد norazlina | mohamed norazlina
department of pharmacology, faculty of medicine, universiti kebangsaan malaysia medical centre, kuala lumpur, malaysia
نشانی اینترنتی http://ijbms.mums.ac.ir/article_9610.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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