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Medical Journal of Islamic Republic of Iran، جلد ۲۶، شماره ۲، صفحات ۹۰-۹۳
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عنوان انگلیسی The role of Human papilloma virus (HPV) genotyping in recurrent respiratory papillomatosis in Rasoul Akram Hospital
چکیده انگلیسی مقاله  Background: The most common laryngeal mass in children is recurrent respiratory papillomatosis (RRP). Studies have attempted to correlate viral typing and its aggressiveness. Method: 29 patients with histologically confirmed RRP enrolled in adjuvant therapies. Patients underwent several surgical interventions. Results: HPV genotyping demonstrated 45% HPV-6 and 55% HPV-11. The mean age at the first surgical intervention was 52.39 months (SD=102.28) (range from 4 months to 426 months). The mean number of surgical intervention was 10.39 (SD=7.76) (range from 2 to 30). The mean time of surgical intervals was 4.63 months (SD=4.02) (range from 2 to 24 months). In fourteen patients (48%) tracheotomy was done. All patients who had tracheotomy received alpha-interferon. One of our cases was a male who had pulmonary extension with HPV-6. Conclusion: A review of patients with RRP was regarding to HPV genotyping and need for adjuvant therapy and tracheostomy. Mean number of surgical procedure was 10/40 and nearly fourteen patients (48%) need to tracheotomy. The clinical differences between HPV6 and HPV11 disease may not be accurately predictable. Patients with less age and with HPV-11 seemed to have more severe problems, but these differences were not statistically significant which needs much more investigations for reasonable starting point of evaluation for these differences.
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نویسندگان مقاله فرزاد ایزدی | farzad izadi
department of otolaryngology, ent.hns research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: ENT.HNS research center

رسول همکار | rasool hamkar
department of virology, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

هادی قنبری | hadi ghanbari
department of otolaryngology, ent.hnsresearch center, tehran university of medical sciences. rasoul akram hospital niayesh st. sattarkhan avenue, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: ENT.HNSresearch center,

فرشته فرشته | fereshteh abdolmotallebi
department of otolaryngology, ent.hns research center, tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: ENT.HNSresearch center,

حسام جهاندیده | hesam jahandideh
department of otolaryngology, ent.hns research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: ENT.HNSresearch center,

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-304&slc_lang=en&sid=en
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