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Medical Journal of Islamic Republic of Iran، جلد ۲۶، شماره ۱، صفحات ۱-۶
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عنوان انگلیسی Mast cells density in fibrotic capsule of enchondroma and well-differentiated chondrosarcoma: a method for histopathologic differentiation
چکیده انگلیسی مقاله  Background: An enchondroma is a benign and a well-differentiated chondrosarcoma is an invasive chondroid tumor with high recurrence potential. In spite of biologic differences, these two tumors have very similar histopathologic appearance. It has been shown that the biologic nature of the connective tissue around benign and malignant tumors varies in the number of mast cells. The aim of this study was to study the histopathologic distinction of enchondroma and well-differentiated chondrosarcoma using the density of the mast cells in fibrotic capsule. Methods: Twelve enchondroma and 15 well-differentiated chondrosarcoma were collected from Pathology department of Cancer Institute and Central Pathology department of Imam Khomeini Hospital in Tehran. 3 micron paraffin embedded tissue sections were stained by toluidine blue for mast cells counting. Mast cells were counted in fibrous capsule of all cases. Mast cells counts were accomplished in 10 high power fields .The average number of mast cells in 10HPF was determined as an index for each lesion. Mann-Whitney U test was used for statistical analysis. Results: Mean index in enchondroma and well-differentiated chondrosarcoma groups were 0.1±0.12 and 0.31±0.33 respectively, showing a significant difference between number of mast cells in the fibrotic capsule in these two lesions (p=0.028). Comparison of the corresponding points in ROC curve, showed a cut-off point = 0.15, with positive predictive value of 61%, negative predictive value 71%, specificity of 33.3% and sensitivity of 66.7%, (p=0.025). Conclusion: Average density of the mast cells in the surrounding fibrotic capsules of enchondroma and well-differentiated chondrosarcoma along with other criterions, could be a beneficial factor for histologically differentiation between these two lesions.
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نویسندگان مقاله نوشین جلایر نادری | noushin jalayer naderi
oral and maxillofacial pathology dept, faculty of dentistry, shahed university. tehran, iran.

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

شمس شریعت tarabghan | shams shariat tarabghan
pathology dept, institute cancer, tehran, iran.


محسن مرآتی | mohsen merati
dental researches center, faculty of dentistry, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
سازمان های دیگر: Dental researches cente

مهدی عاشوری | mahdi ashouri


علی مجیدی | ali majidi
shahed university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

محمد جواد خرازی فرد | mohammad javad kharazi fard
dental research center. tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سازمان های دیگر: Dental researches cente

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-290&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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