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Medical Journal of Islamic Republic of Iran، جلد ۱۶، شماره ۴، صفحات ۲۱۳-۲۲۰
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عنوان انگلیسی ISOLATION OF MYELIN BASIC PROTEIN AND DETECTION OF I TS IMMUNOL'OGICAL PROPERTIES
چکیده انگلیسی مقاله Multiple sclerosis (MS) is an inflammatory disease of the central nervous system of presumed autoimmune etiology. One of the best animal models of demyelinating diseases is experimental autoimmune encephalomyelitis (EAE), which can be induced in a variety of animals by injection of a target antigen such as myelin basic protein (MBP). The immune responses against the target amino acids cause tissue damages such as demyelination in the CNS. In this study, after isolation of myelin basic protein from bovine cord, we examined its purity and molecular weight by SDS-PAGE and in order to investigate its immunological properties, two varieties of guinea pigs were injected with different amounts of the isolated protein. Clinical signs of EAE and also histological changes were detected. Delayed type hypersensitivity, and anti-MBP antibodies to the isolated MBP were also investigated. Another form of EAE which has been called chronic-relapsing EAE (CR-EAE), was induced by injection of cord homogenate. EAE and CR-EAE are the best models for MS investigations.
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نویسندگان مقاله f مختاری | f mokhtari
from the center of researches for biology and microbiology, institute of standard and industrial research of iran, karaj,


s رفیعی | s rafeie
thedepartment of immunology, school of medicine, tehran university of medical sciences,tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

e کیهانی | e keyhani
the institute of biochemistry and biophysics, tehran university, tehran, i.r. iran.

سازمان اصلی تایید شده: مرکز تحقیقات بیوشیمی و بیوفیزیک (Institute of biochemistry and biophysics)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-192&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Biological Sciences
نوع مقاله منتشر شده Original Research: Basic Science in Medicine
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