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Auditory and Vestibular Research، جلد ۲۲، شماره ۳، صفحات ۴۲-۵۱
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی The effect of the age of treatment onset and quality of dietary control on language and intelligence functions in patients with Phenylketonuria
چکیده انگلیسی مقاله Background and Aim: Phenylketonuria (PKU) is an inherited metabolic disease. The aim of this study was investigation the intelligence and language function in children with PKU based on the age of treatment onset and quality of dietary control. Methods: In this cross-sectional study, the language and intelligence of 31 children with PKU at the age of 4 to 6.5 years were investigated by test of language development-third edition (TOLD-3) and Wechsler preschool and primary scale of intelligence (WIPPSI), respectively; the data compared with of 42 normal children. Patients were classified into 2 groups with different level of dietary control as good and poor [serum phenylalanine (Phe) level less and more than 6 mg/dl, respectively]. Results: There were significantly differences (p=0.001) between children with PKU and controls in intelligence and language scores. Early treatment improved significantly the intelligence and language scores in comparison with late treatment (p=0.019). Comparing late treatment before and after the age of 1 year showed that late treatment until 1 years of age improved significantly (p=0.050) all of functions except performance intelligence quotient (IQ). In early treated PKU, good dietary control improved significantly (p=0.021) and also, verbal and total IQ in comparison with poor dietary control. Conclusion: Although, the language development in children with PKU is affected by age of treatment onset, cognitive development features such as verbal and total IQ is affected not only by the time of treatment onset but also by the quality of dietary control.
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نویسندگان مقاله نسرین کرامتی | nasrin keramati
department of speech therapy, school of rehabilitation, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

zarha سلیمانی | zarha soleymani
endocrine research centre, institute of endocrinology and metabolism, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

فرزانه روحانی | farzaneh rouhani
department of biostatistics, school of rehabilitation, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهره جلایی | shohreh jalaie
infection research centre, mofid children hospital, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

محمدرضا علایی | mohammad reza alaee


نشانی اینترنتی http://avr.tums.ac.ir/index.php/avr/article/view/293
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Research Article(s)
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