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Iranian Journal of Kidney Diseases، جلد ۵، شماره ۳، صفحات ۱۸۲-۰
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عنوان انگلیسی Effect of Hepatitis C Virus on C-Reactive Protein and Interleukin-6 in Hemodialysis Patients
چکیده انگلیسی مقاله Introduction. Patients with end-stage renal disease are at a high risk of hepatitis C virus (HCV) infections. These patients are on maintenance hemodialysis where they are exposed to dialysis fluid and dialysis membrane that generate an acute-phase response, which leads to inflammation, reflected in increased inflammatory markers like C-reactive protein (CRP) and interleukin-6 (IL-6). The aim of this study was to investigate levels of IL-6 and CRP in patients on hemodialysis and to determine effects of HCV on these markers. Materials and Methods. A total of 43 patients (39.5% men and 60.5% women; age range, 21 to 65 years) on maintenance hemodialysis for a period of at least 3 months were included. Twenty-four of them were HCV positive. Serum IL-6 and CRP were assessed in all patients. Results. Of HCV-positive patients, 11 (45.8%) had high levels of CRP, while 13 (54.2%) had low levels and increased levels of IL-6 (1064 ± 544.2 pg/mL, P = .19). Of 19 HCV-negative patients, 13 (68.4%) had high levels of CRP, while 6 (31.6%) had low levels, and all these patients had low levels of IL-6, as compared to HCV-positive patients. No significant correlation was observed between the levels of CRP or IL-6 and the duration of dialysis. Conclusions. In our study, we found high serum IL-6 and CRP levels in HCV-positive hemodialysis patients, compared with HCV-negative ones. However, we failed to show the significance of these differences. More studies with large sample sizes and evaluation of the other inflammatory markers are warranted.
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نویسندگان مقاله ندیم افضل | nadeem afzal


sarwar عباس | sarwar abbas


azazmand احمد | azazmand ahmed


ماریا عارف | maria arif


khursheed javeed | khursheed javeed


نشانی اینترنتی http://www.ijkd.org/index.php/ijkd/article/view/412
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Dialysis
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