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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۲، شماره ۱، صفحات ۴۹-۵۶
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عنوان انگلیسی Association between (GT)n Repeats in Heme Oxygenase-1 Gene Promoter and 3-Year Survival of Patients with Acute Leukemia: A Controlled, Cross-Sectional Study
چکیده انگلیسی مقاله Background: Acute leukemia is a common pediatric cancer. Novel strategies for treatment of acute leukemia have been developed, but treatment resistance has remained as the most problematic issue. It is hypothesized that the HO-1 gene up-regulation is responsible for tumor resistance to chemotherapy or radiotherapy-induced apoptosis. HO-1 expression levels have been related to (GT) n microsatellite polymorphisms in the location of its promoter.This study designed to compare allelic frequencies of (GT) n microsatellite polymorphisms in HO-1 gene between acute leukemia patients and healthy controls. Indeed, 3-year disease-free survival was also evaluated. Materials and Methods: The study included 63 acute leukemia patients and 70 healthy infants. We used patient’s medical records to collect data regarding the post-chemotherapy survival. The number of GT repeats in HO-1 promoter was determined by an ABI 3100 sequencer. Results: The HO-1 GT repeats ranged from 14 to 34 with peaks at 27 repeats in both cases and controls. Children with longer alleles ((GT) n ≥ 27) had enhanced 3-year survival rate after treatment with chemotherapy or radiotherapy (P< 0.05). Conclusion: Although no significant differences were observed between leukemia patients and controls regarding allelic frequency, we found elevated frequency of “LL” genotype in leukemia patients with good 3-year surveillance. Radiotherapy and chemotherapy might elevate the expression levels of HO-1 with subsequent increased resistance of leukemia patients to therapy.
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نویسندگان مقاله محمد کاظمی | mohammad kazemi
medical genetic center of genome, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فریناز خسرویان | farinaz khosravian
isfahan dental student research committee, school of dentistry, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

امیر عباس صامتی | amir abbas sameti
department of pediatric hematology, school of medicine and child health promotion research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علیرضا معافی | alireza moafi
department of epidemiology and biostatistics, school of health, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمدرضا مراثی | mohammad reza merasi
department of genetics and molecular biology, school of medicine, isfahan university of medical sciences, isfahan, iran pediatric inherited diseases research center, research institute for primordial prevention of non-communicable disease, isfahan university of medical sciences, isfahan, iran medical genetic center of genome, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

منصور صالحی | mansour salehi
anatomical sciences research center, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

مجید نجاتی | majid nejati
rajaie cardiovascular medical and research center, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محدثه بهجتی | mohaddeseh behjati


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/708
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