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Iranian Journal of Microbiology، جلد ۹، شماره ۶، صفحات ۳۱۲-۳۱۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The high prevalence of Mycobacterium tuberculosis Beijing strain at an early age and extra-pulmonary tuberculosis cases
چکیده انگلیسی مقاله Background and Objectives: Tuberculosis (TB) is still responsible for a wide range of deaths worldwide. Beijing genotype is one of the most important and virulent strains in Mycobacterium tuberculosis . This study was designed for determination Beijing genotypes of M. tuberculosis in Golestan province, north of Iran. Materials and Methods: In the current descriptive study, 238 clinical MTB isolates, obtained from patients with pulmonary and extra-pulmonary TB in north of Iran, were evaluated. Oligonucleotide primers for the Beijing and non-Beijing genotypes and specific probes for their detection by a real-time PCR method were employed. In addition, an association between the Beijing genotype and possible clinical and demographic factors was evaluated. Results: The method revealed that 33 cases (13.9%) were the Beijing lineage and 205 (86.1%) the non-Beijing genotype. The mean age of patients infected with the Beijing and non-Beijing strains was 37.27 ± 18.3 and 51 ± 21.2 years, respectively; the difference was statistically significant (P = 0.001). In addition, the prevalence of the Beijing strain decreased with age. Patients with a TB infection caused by the Beijing genotype were also more vulnerable to treatment failure. Based on the origin of the samples, the Beijing genotype was more often observed in extra-pulmonary samples compared with Pulmonary ones (P = 0.001). Conclusion: The Beijing genotype of MTB is prevalent in our region especially among young people which could indicate the risk of further expansion in the future.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله حنیفه ایری | hanifeh erie
department of microbiology, ayatollah amoli branch, islamic azad university, amol, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

حامی کابوسی | hami kaboosi
department of microbiology, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

ناعمه جاوید | naeme javid
infectious diseases research center, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

حسام الدین شیرزاد اسکی | hesamaddin shirzad aski
tuberculosis laboratory center, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

معصومه تازیکی | masoumeh taziki
department of microbiology, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

مایا بابایی kuchaksaraee | maya babaee kuchaksaraee
department of microbiology, golestan university of medical sciences, gorgan, iran; laboratory sciences research center, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

عزت اله قایمی | ezzat allah ghaemi


نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/1290
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/91/article-91-565924.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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