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Medical Journal of Islamic Republic of Iran، جلد ۳۱، شماره ۱، صفحات ۷۶۲-۷۶۷
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عنوان انگلیسی Comparison of hematological parameters, iron levels, and oxidative stress in women with and without breast cancer: A case- control study
چکیده انگلیسی مقاله     Background: Iron is one of the nutrients that has recently received considerable attention because of its dual role in the incidence of breast cancer. The present study aimed at comparing hematological parameters, iron levels, and oxidative stress in women with and without breast cancer.    Methods: The participants in this case-control study were 55 women, of whom 26 were new cases of breast cancer (confirmed by biopsy) as the case, and 29 without cancer (confirmed by mammography) as the control group. All participants underwent blood testing for complete blood count (CBC (free iron, ferritin, total iron binding capacity) TIBC (2, 2-diphenyl-1-picrylhydrazyl (DPPH), and Malondialdehyde (MDA).    Results: The mean±SD age of the participants was 44.25±9.82 years, and there was no significant difference between groups. Also, no statistically significant difference was found between the 2 groups in variables, except the mean corpuscular volume of red cells (MCV), mean corpuscular hemoglobin concentration (MCHC), and mean cell hemoglobin (MCH). The use of iron supplements was significantly higher in the control than in the case group (p= 0. 01), with an odds ratio of 0.19% (95% CI: 0.45-0.7). The mean serum DPPH was significantly higher in the control than in the case group (p= 0. 006), but comparison of serum MDA showed no significant difference between the 2 groups.    Conclusion: Iron deficiency anemia was greater in patients with breast cancer than in those without it. Moreover, iron supplementation appears to have a protective effect against breast cancer incidence. In addition, serum DPPH, as a total antioxidant index, was significantly higher in the control group.  
کلیدواژه‌های انگلیسی مقاله Iron status, Breast cancer, Oxidative stress, Premenopausal
نویسندگان مقاله افسانه راجی زاده | afsaneh rajizadeh
nutrition and food security research center, shahid sadoughi university of medical sciences, yazd, iran amp; department of nutrition, school of public health, shahid sadoughi university of medical sciences, yazd, iran.


حسن مظفری خسروی | hassan mozaffari khosravi
department of nutrition, school of public health, shahid sadoughi university of medical sciences, yazd, iran amp; yazd diabetic research center, shahid sadoughi university of medical sciences, yazd, iran.


جواد زوار رضا | javad zavar reza
department of biochemistry, faculty of medicine, shahid sadoughi university of medical sciences, yazd, iran.


سید مصطفی شیریزدی | seyyed mostafa shiryazdi
department of general surgery, shahid sadoughi university of medical sciences, yazd, iran.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3130-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/18/article-18-567954.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nutrition
نوع مقاله منتشر شده Original Research
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