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Medical Journal of Islamic Republic of Iran، جلد ۳۱، شماره ۱، صفحات ۶۹۹-۷۰۴
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عنوان انگلیسی Probiotics improve insulin resistance status in an experimental model of Alzheimer’s disease
چکیده انگلیسی مقاله     Background: Nowadays, Alzheimer's disease (AD) is considered as Type 3 diabetes in which insulin resistance is the common cause of both diseases. Disruption of insulin signaling cascade and insulin resistance can induce AD; and central insulin resistance causes systemic alterations in serum insulin, FBS levels, and lipid profile. Studies have shown that probiotics (Lactobacillus and Bifidobacterium species) can be used as a nutritional approach to improve these metabolic changes. We assessed the probiotic effect (4 species of Lactobacillus and Bifidobacterium) on insulin resistance biomarkers in an experimental model of AD.    Methods: A total of 60 rats were divided into 5 groups: (1) a control group without surgical and dietary intervention; (2) a control-probiotics group receiving probiotics for 8 weeks, but not receiving any surgical intervention; (3)  a group receiving a sham operation in which PBS was injected intrahippocampus  but  without dietary intervention; (4) an Alzheimer group for which Amyloid-ß (Aß) 1-42 was injected intrahippocampus but without dietary intervention; (5) and an Alzheimer-probiotics group for which Aß1-42 was injected intrahippocampus and given 2g probiotics for 8 weeks. The FBS levels and lipid profile were measured by a calorimetric method, insulin levels were detected by an ELISA kit, and HOMA-IR was calculated using a formula. ANOVA (one way analysis of variance followed by Bonferroni comparisons post hoc) was used to compare all the variables between groups.     Results: Serum glucose, insulin levels, and HOMA-IR index increased in the Alzheimer group compared to the control (p< 0.001), while probiotics decreased only insulin level and HOMA-IR index in AP group compared to Alzheimer group (p< 0.001). Also, TG levels increased in the Alzheimer group (p< 0.001), but no significant difference was detected between Alzheimer and Alzheimer-probiotics group.    Conclusion: It seems that probiotics play an effective role in controlling glycemic status of Alzheimer's disease.  
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نویسندگان مقاله سمیه اطهاری نیک عزم | somayeh athari nik azm
department of community nutrition, school of nutritional science and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ابوالقاسم جزایری | abolghassem djazayeri
department of community nutrition, school of nutritional science and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مجید صفا | majid safa
cellular and molecular research center and hematology department, school of allied medical science, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

کیان اعظمی | kian azami
department of pharmacology, pharmaceutical science research center, faculty of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمود جلالی | mahmoud djalali
department of cellular-molecular nutrition, school of nutritional science and dietet-ics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد شریف زاده | mohammad sharifzadeh
department of pharmacology and toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا وفا | mohammadreza vafa
department of nutrition, school of public health, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-70-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/18/article-18-567964.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nutrition
نوع مقاله منتشر شده Original Research
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