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Physiology and Pharmacology، جلد ۲۱، شماره ۴، صفحات ۳۱۲-۳۲۱
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عنوان انگلیسی Anti-diabetic effect of aqueous extract Crocus sativus L. in tartrazine induced diabetic male rats
چکیده انگلیسی مقاله Introduction: In this study, we evaluated the antidiabetic and antidiabetogenic effect of saffron against diabetes induced by artificial dye tartrazine on normal male rats. Methods: Dried saffron was macerated for 12 hours in distilled water before usage and crude extract was used to treat male rats. Rats were divided into 5 groups consisted of 6 rats and treatment was performed daily and orally. Group-1 treated with distilled water, group-2 with tartrazine 10mg/kg followed by saffron 120mg/kg until the last day of treatment, group-3 administered with tartrazine, group-4 treated with saffron for 60 days and administered with tartrazine, group-5 with saffron for 105 days. Levels of blood glucose and body weight have been evaluated every 10 days and clinical demonstrations and metabolic parameters were evaluated at the end of the experiment. Results: Levels of blood glucose and body weight have been evaluated every 10 days and clinical demonstrations and metabolic parameters were evaluated at the end of the experiment. Results showed that treatment with tartrazine and saffron did not affect body weights, metabolic parameters but changed the blood glucose levels after 105 days of administration. The levels of glucose and creatinine were significantly increased in group-2 and group-3 compared to control group (P< 0.05). There was no significant difference in the level of glucose, creatinine in group4 (P>0.05). Treatment with saffron decreases creatinine level. Conclusion: The outcomes suggest that saffron has curative (antidiabetic) and protective (antidiabetogenic) effect against diabetes induced by tartrazine via reducing blood glucose level and creatinine. Therefore, it should be considered in future therapeutic researches.
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نویسندگان مقاله iliass lahmass | iliass lahmass
université mohamed premier, faculty of sciences, department of biology, laboratory of biochemistry, oujda, morocco


assia صابونی | assia sabouni
université mohamed premier, faculty of sciences, department of biology, laboratory of biochemistry, oujda, morocco


محمد elyoubi | mohammed elyoubi
université mohamed premier, faculty of sciences, department of biology, laboratory of biochemistry, oujda, morocco


ردوانه benabbes | redouane benabbes
université mohamed premier, faculty of sciences, department of biology, laboratory of biochemistry, oujda, morocco


اسلیمان مختاری | slimane mokhtari
regional laboratory of medical analysis, hôpital al farabi, oujda, morocco


ennouamane saalaoui | ennouamane saalaoui
université mohamed premier, faculty of sciences, department of biology, laboratory of biochemistry, oujda, morocco
نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-998-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/26/article-26-568089.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacology
نوع مقاله منتشر شده Original Research
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