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Iranian Journal of Medical Sciences، جلد ۴۳، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice
چکیده انگلیسی مقاله Background: Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ)-induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol. Methods: PTZ (100 mg/kg) was used for the induction of seizure in 72 male albino Swiss strain of mice (n=8). Opipramole (10, 20, and 50 mg/kg), ketamine (50 mg/kg), caffeine (200 mg/kg), opipramole (20 mg/kg) plus ketamine (50 mg/kg), opipramole (20 mg/kg) plus caffeine (200 mg/kg), diazepam (5 mg/kg as a positive control), and the vehicle were administered interaperitoneally 30 minutes before the injection of PTZ. The latency was recorded for the clonic, tonic-clonic seizures, and death of animals after the injection of PTZ. Kruskal-Wallis test followed by Dunn’s test was used for the analysis of data. Statistical analysis was performed with the SPSS software version 23.0 and P< 0.05 was considered as the significant level. Results: Opipramol (20 mg/kg) increased the latency for the PTZ-induced clonic (44%, P=0.021) and tonic-clonic (130.80%, P=0.043) seizures compared with the vehicle-treated group. Animals treated with opipramol (20 mg/kg) plus caffeine (200 mg/kg) had a significantly higher onset of PTZ-induced clonic and tonic-clonic seizures compared with the control (P=0.046 and 0.000, respectively). Ketamine combined with opipramol increased the onset of tonic-clonic seizure compared with the vehicle-treated groups (P< 0.001). Conclusion: Opipramol attenuated the seizures induced by the PTZ. Ketamine and caffeine had no effect on the anticonvulsant activity of opipramol.
کلیدواژه‌های انگلیسی مقاله Opipramol, Sigma, Pentylenetetrazole, Ketamine, Caffeine
نویسندگان مقاله مجتبی کشاورز | mojtaba keshavarz
school of medicine, bushehr university of medical sciences, bushehr, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

بهداد yekzaman | behdad yekzaman


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/3291
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-574101.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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