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Medical Laboratory Journal، جلد ۱۲، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori
چکیده انگلیسی مقاله   ABSTRACT Background and Objectives:Helicobacter pylori is the most common causes of gastritis and ulcers whose treatment sometimes fails due to its resistance to drugs. This study has been carried out to investigate the antimicrobial effects of the bacteria existing in the camel milk on the growth of clinical strains of drug-resistant Helicobacter pylori. Methods:In this cross-sectional study, biopsy samples of 75 patients with digestive symptoms were transferred to laboratory in the transport medium containing homogeneous compounds.In order to isolate Helicobacter pylori, urease positive biopsies were promptly cultured in the Brucella agar medium enriched with defibrinated sheep blood and fetal calf serum which were selected by antibiotics. Disk diffusion agar test was used to determine drug susceptibility and agar well diffusion method was applied to study the antagonistic effect of probiotics isolated from camel milk. Results:In this study, the frequency of Helicobacter pylori isolates was reported to be 42.7%. Most resistance was against metronidazole (56.3%).Resistance rates were: amoxicillin (31.3%), ciprofloxacin (18.8%), clarithromycin and tetracycline (15.6%). Lactobacillus plantarum (59.3%) was more frequent than other Lactobacilli species, though all the three species of Lactobacillus plantarum, Lactobacillus fermentum and Lactobacillus casei showed a proper inhibitory effect but Lactobacillus plantarum with the average diameter of 20.3 mm, having the most inhibitory effect. Conclusion: Considering the increasing trend of resistance to drugs and the inhibitory effect of isolated probiotics, it seems logical to use a probiotic diet in treating infections resulting from gastrointestinal diseases pathogens. Keywords: Helicobacter pylori, Drug resistance, Camel milk, Probiotic  
کلیدواژه‌های انگلیسی مقاله Helicobacter pylori, Drug resistance, Camel milk, Probiotic
نویسندگان مقاله | Afsaneh Sikarchi
Microbiology, Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran


| Leila Fozouni
Department of Biology, Islamic Azad University, Gorgan Branch, Gorgan, Iran
نشانی اینترنتی http://goums.ac.ir/mljgoums/browse.php?a_code=A-10-1-509&slc_lang=fa&sid=en
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