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Medical Journal of Islamic Republic of Iran، جلد ۲۴، شماره ۳، صفحات ۱۶۳-۱۶۸
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عنوان انگلیسی Meningeal melanomas associated with transforming Ota nevus to malignant melanoma: a case report
چکیده انگلیسی مقاله Absract Intracranial invasion of cellular blue nevus (CBN) from the skin is extremely rare and such a condition with malignant transformation is even rarer. A case of meningeal melanoma with malignant transformation which was derived from an Ota nevus is presented in this report. A21-year-old man with a neurocutaneous syndrome since childhood was referred with headache and mild left hemiparesia. CT scan and MRI demonstrated intracranial lesions and conjunctival biopsy leads to the pathologic diagnosis of blue nevus. Thereafter his parietal lesion was operated by craniotomy with total gross excision. On histopathological examination, diagnosis of malignant melanoma was confirmed. Approximately 2 months after radiotherapy and chemotherapy, he afflicted to diplopia and blurred vision on the leftside due to enlargement of orbital and cavernous sinus lesion. Following one year follow-up, he was survived and thrived with diffuse leptomeningeal nodular enhancement in favor of melanoma dissemination. Primary intracranial melanomas are though rare, but it should be suspected especially in the presence of periorbital blue nevus or nevus of Ota. Moreover, although CBN is considered benign, scalp or periorbital CBN has the potential for intracranial invasion and malignant transformation.
کلیدواژه‌های انگلیسی مقاله Meningeal Melanomas, Ota nevus, Malignancy
نویسندگان مقاله مازیار آذر | maziar azar
department of neurosurgery, iran university of medical sciences and health services , tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

فرید کاظمی | farid kazemi
department of neurosurgery, iran university of medical sciences and health services , tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

اسحاق بهرامی | eshagh bahrami
department of neurosurgery, iran university of medical sciences and health services , tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

ابراهیم حجازیان | ebrahim hejazian
department of neurosurgery, iran university of medical sciences and health services

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سید محمد فرشته نژاد | seyed mohammad fereshtehnejad
iran university of medical sciences and health services, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

علی احمدی | ali ahmadi
department of neurosurgery, iran university of medical sciences and health services, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مسیح یساری | masih yasari
department of neurosurgery, iran university of medical sciences and health services, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-121&slc_lang=en&sid=en
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