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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۲، شماره ۲، صفحات ۱۱۷-۱۲۲
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عنوان انگلیسی Cholelithiasis in Thalassemia Major Patients: A Report from the South-East of Iran
چکیده انگلیسی مقاله Background: Cholelithiasis and its predisposing factors are less characterized in thalassemia syndromes. In the present study, we assessed the prevalence of gallstones and related-risk factors among thalassemia major (TM) patients in south-east of Iran. Materials and Methods: The patients were recruited form a single center in Zabol city, south-east of Iran. Demographic and clinical information were retrieved from medical histories. Abdominal ultrasonography was performed to scrutinize gallstones and organ dimensions of liver, spleen, gallbladder and kidney. Results: The study participants (n=127) consisted of 50 (39.4%) males and 77 (60.6%) females. The mean age of the patients was 15.2±7.9 years . Cholelithiasis was observed in 11 (8.7%) patients. Cholelithiasis was significantly associated with age ( P =0.002) and splenectomy ( P =0.001). The patients with cholelithiasis received a significantly higher blood volume than patients without cholelithiasis (546±108.7 ml and 425.1±134.7 ml, respectively, P =0.007). There were significant differences between cholelithiasis and non- cholelithiasis TM patients regarding the length of right and left liver lobes ( P =0.001), as well as the length of gallbladder ( P =0.006). Ferritin level was not associated with cholelithiasis in our patients. In multivariate analysis, age older than 15 (OR=10.4, 95% CI: 1.2-86.3, P =0.02) and 30 years old (OR=42.6, 95% CI: 2.9-613, P =0.006), and splenectomy (OR=8.7, 95% CI: 2.1-35.4, P =0.002) was significant risk factor for cholelithiasis. Conclusion: Cholelithiasis is a relatively common complication among TM patients in our region. The most prominent risk factors of cholelithiasis were advanced age, splenectomy and large-volume blood transfusion.
کلیدواژه‌های انگلیسی مقاله Cholelithiasis, Gallstone, Thalassemia
نویسندگان مقاله | Iraj Shahramian
Department of Radiology, Zabol University of Medical Sciences, Zabol, Iran


| Razieh Behzadmehr
Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran


| Mahdi Afshari
Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran


| Atefeh Allahdadi
Pediatric Digestive and Hepatic Research Center, Zabol University of Medical Sciences, Zabol, Iran Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran


| Mojtaba Delaramnasab
Pediatric Digestive and Hepatic Research Center, Zabol University of Medical Sciences, Zabol, Iran


| Ali Bazi


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/798
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