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Medical Journal of Islamic Republic of Iran، جلد ۲۴، شماره ۳، صفحات ۱۲۶-۱۳۲
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عنوان انگلیسی Effect of oral supplementation of zinc on treatment of otitis media with effusion
چکیده انگلیسی مقاله Abstract Objective: To determine the effect of oral zinc sulfate supplementation given with coamoxiclav when compared with coamoxiclav alone for treatment of otitis media with effusion (OME). The efficacy of the drug was assessed 3 and 6 weeks after administration . Methods: In a double-blind, randomized trial 4 to 14 years old children with OME who referred to ear, nose and throat clinic, were randomly assigned into two groups : 1) Zinc group: Zinc sulfate + Coamoxiclav + Pseudoephedrine + Nacl nasal drop 2) Placebo group: Placebo + Coamoxiclav + Pseudoephedrine + Nacl nasal drop . Atotal of 52 children were studied consisting zinc group 29 and placebo group 23 children. Children were examined by otoscopy and tympanometry at entry and after 3 weeks of treatment. For children who had not been cured completely after 3 weeks , treatment continued for more 3 weeks (total of 6 weeks ( . Results: At the end of the first course of treatment (3 weeks) 62.1% of children in the zinc group had clinical improvement compared with 43.5% of children in placebo group. Tympanometrically, 70.9% of children in zinc group had improvement compared with 65.5% for placebo group with no statistically significant difference . There was no significant difference between the two groups at the end of second course of treatment (6 weeks). But the response rate of zinc group was better than the placebo group (43.8% versus 12.5% clinically and 56.3% versus 40% tympanometricall). Zinc administration and cycles of treatment had no significant relationship . Conclusion: Although in this study oral zinc sulfate supplementation had not significant effect on treatment of OME, the response rate was better in zinc group compared to placebo group specially in longer administration . According to the findings, it seems more studies about oral zinc supplementation in the treatment of OME is needed .
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نویسندگان مقاله پوپک ایزدی | poopak izadi
shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

محمد ابراهیم یارمحمدی | mohammad ebrahim yarmohammadi
shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

ناهید خلدی | nahid kholdi
shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

بابک ایزدی | babak izadi
kermanshah university, kermanshah, iran


ساسان اناری | sasan anari


مرتضی سدهی | morteza sedehi
shahed university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-115&slc_lang=en&sid=en
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