این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۲۴، شماره ۳، صفحات ۱۲۱-۱۲۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of classical cytogenetics versus interphase FISH in diagnosis of mosaic form of Turner syndrome
چکیده انگلیسی مقاله  Abstract Background: Mosaic form of turner syndrome that represented by two or more cell lines in an affected individual, often has limitation for detection with classical cytogenetic methods. The present study was carried out to compare the efficiency of interphase Fluorescence In Situ Hybridisation (FISH) and cytogenetic techniques in detection of mosaic form of turner syndrome. Methods: All candidate samples for turner syndrome were surveyed with both interphase FISH using DXZ1 as a chromosome X specific probe and the GTG- banding methods. The chi square test was used and a P-value of less than 0.05 was considered as being significant. Results: Asignificant difference was observed between results obtained from the application of the two methods under study (P< 0.05), indicating that the interphase FISH is favourably compares to conventional cytogenetics in detection of mosaic form of X chromosome aneuploidy, as an extended number of cells can be scored in a limited time. Conclusion: The results indicate that using the two techniques in parallel allow accurate differentiation between mosaicism and homogenous aneuploidy of X chromosome, and thus both numerical and structural aberrations of the X will be analyzed.
کلیدواژه‌های انگلیسی مقاله Turner syndrome, mosaicism, FISH, clasical cytogenetics
نویسندگان مقاله سید مجتبی محدث | seyed mojtaba mohaddes
department of medical genetics, faculty of medicine, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

شهره شرق | shohreh shargh


سیمین تقوی | simin tagavi


نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-114&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 1
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات