| چکیده انگلیسی مقاله |
Introduction: Breast cancer is the most common malignancy and the second leading cause of death due to cancer in women following lung cancer. Ample evidence has shown the antitumor activities of curcumin in breast cancer in preclinical and clinical trials. The anticancer effects of curcumin include the inhibition of cancer cell formation, angiogenesis, and tumor growth. Due to the low absorption of curcumin in the gastrointestinal tract, as well as its low water solubility, rapid metabolism, and high excretion, curcumin has low bioavailability. Therefore, using formulated curcumin could increase its bioavailability. The present study aimed to evaluate the effects of curcumin and its nano-formulated compositions in the prevention and treatment of breast cancer. Methods: In this review, data were collected via searching in databases such as PubMed, Scopus, Google Scholar, and Magiran to identify the related English and Persian articles published until 2016 using keywords such as nano-forms, clinical study, cancer, breast, and curcumin. In total, 40 studies were identified and reviewed. Results: Using formulated curcumin could increase its absorption and bioavailability, while it also enhances its effects on cancer cells, including breast cancer cells. Therefore, nano-formulated curcumin was observed to be effective in the prevention and treatment of breast cancer. Conclusion: Considering the higher bioavailability of the formulated compounds of curcumin compared to its free form and the low toxicity of this herbal medicine, curcumin could be used in combination with other anticancer medications in the treatment of breast cancer. |
| نویسندگان مقاله |
میلاد هاشمزهی | Milad Hashemzehi
PhD Candidate, Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
دانشجوی دکتری فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
امیر آوان | Amir Avan
Assistant Professor, Department of Genetics, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استادیار گروه ژنتیک، مرکز تحقیقات سرطان و گروه فناوریهای نوین، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
ملیحه حسنزاده | Maliheh Hasanzadeh
Professor, Department of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استاد گروه زنان و مامایی، مرکز تحقیقات سلامت زنان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
سودابه شهید ثالث | Soodabeh Shahid Sales
Associate Professor, Department of Oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
دانشیار گروه انکولوژی، مرکز تحقیقات سرطان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
زهره یوسفی | Zohreh Yousefi
Assistant Professor, Department of Genetics, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استادیار گروه ژنتیک، مرکز تحقیقات سرطان و گروه فناوریهای نوین، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
سیما کدخدایان | Sima Kadkhodayan
Professor, Department of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استاد گروه زنان و مامایی، مرکز تحقیقات سلامت زنان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
مرجانه فرازستانیان | Marjaneh Farazestanian
Assistant Professor, Department of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استادیار گروه زنان و مامایی، مرکز تحقیقات سلامت زنان، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
مونا جودی مشهد | Mona Joudi Mashhad
Assistant Professor, Department of Radiation Therapy, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استادیار گروه پرتودرمانی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
مجید خزاعی | Majid Khazaei
Professor, Department of Physiology, Neurogenic Inflammation Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استاد گروه فیزیولوژی، مرکز تحقیقات التهاب نوروژنیک و گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
سید مهدی حسنیان | Seyed Mahdi Hassanian
Assistant Professor, Department of Medical Biochemistry, Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استادیار گروه بیوشیمی بالینی، مرکز تحقیقات سندرم متابولیک و گروه بیوشیمی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
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