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Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۳، صفحات ۲۵۸-۲۶۳
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عنوان انگلیسی Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)
چکیده انگلیسی مقاله   The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HAM/TSP by comparing frequencies of promoter region single nucleotide polymorphisms in HTLV-I infected Iranian patients who either remained asymptomatic or developed HAM/TSP and asymptomatic HTLV-I carriers. Healthy, uninfected individuals from the same region served as healthy controls. Significant differences were observed in the distribution of IL-10 promoter alleles and genotypes at position -819 and -592 between HAM/TSP patients and healthy controls (P=0.01), and between HTLV-I carriers and healthy controls (P=0.02). The frequency of the low IL-10 producer haplotype (-1082*A, -819*T, -592*A) was significantly associated with HTLV-I carriage or HAM/TSP compared with healthy controls (P= 0.02 and 0.01, respectively). Our results suggest that IL-10 -819*T and -592*A alleles are significant risk factors for developing HTLLV-I infection but do not appear to convey additional risk for developing HAM/TSP  
کلیدواژه‌های انگلیسی مقاله Gene HAM/TSP HTLV-I IL-10 Polymorphisms
نویسندگان مقاله | Abbas Shirdel
Department of Hematology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mahmoud Reza Azarpazhooh
Neurology Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Maryam Sahebari
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohsen Ghanbari
Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Seyedeh Zahra Mirfeizi
Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Ian Hutchinson
Immunology Research Group, Faculty of Life Sciences, The University of Manchester, United Kingdom


| Aghigh Ziaee
Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Houshang Rafatpanah
Inflammation and Inflammatory Disease Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_743.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-589920.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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