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Physiology and Pharmacology، جلد ۱۵، شماره ۱، صفحات ۱-۱۵
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عنوان انگلیسی Electrophysiological characteristics of hippocampal CA1 neurons after spreading depression-triggered epileptic activity in brain slices
چکیده انگلیسی مقاله Introduction: A close link between spreading depression (SD) and several neurological diseases such as epilepsy could be demonstrated in many experimental studies. Epilepsy is among the most common brain disorders. Despite a large number of investigations, its mechanisms have not been yet well elucidated. Hippocampus is one of the important structures involved in seizures. The aim of this study is to get an insight into the patho-physiological processes induced by SD that lead to the generation of epileptiform field potentials. Methods: The horizontal amygdala-hippocampus-neocortex slices of rat brain in which SD was induced by KCl application in each brain structure were used. Following GABAA receptor antagonist bicuculline superfusion (1.25 μmol/L, for 45 min), SD induced epileptic activity in all tested slices was monitored. Results: The induction of SD in the hippocampus resulted in interictal and ictal epileptiform field potentials and intracellular paroxysmal depolarization shifts (PDS). After SD, RMP slightly depolarized and the threshold of AP decreased, while the frequency of AP significantly increased. Amplitude of depolarization and also amplitude of discharges were also significantly increased. ISI significantly decreased and the most of neurons shifted from FA to SA indicating an enhanced excitability. Conclusion: SD may cause pathological changes in brain structures such as increased excitation and/or decreased inhibition. Propagation of SD over epileptogenic areas may trigger seizure attacks in some patients and our findings provide evidence on the role of SD in temporal lobe epilepsy.
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نویسندگان مقاله | parviz shahabi
department of physiology, faculty of medical sciences, tarbiat modares university, tehran, ir, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

علی گرجی | ali gorji
westfälische wilhelms-universität münster, institut für physiologie i, münster, germany


یعقوب فتح الهی | yaghoub fathollahi
department of physiology, faculty of medical sciences, tarbiat modares university, tehran, ir, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

مهیار جان احمدی | mahyar janahmadi
neuroscience research centre and department of physiology, medical school, shahid beheshti medical sciences university,tehran, iran.


جواد میرنجفی زاده | javad mirnajafi zade
department of physiology, faculty of medical sciences, tarbiat modares university, tehran, ir, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

جلیل عرب خردمند | jalil arabkheradmand
shefa neuroscience center, tehran, iran


marius الکساندر eickhoff | marius alexander eickhoff
westfälische wilhelms-universität münster, institut für physiologie i, münster, germany
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-21-132&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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