این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۲۴، شماره ۲، صفحات ۵۷-۶۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Polymorphism analysis of malaria susceptibility biomarkers in G6PD deficiency patients
چکیده انگلیسی مقاله Abstract Background: Several studies suggested that some traits and polymorphisms in human genome such as G6PD deficiency and other genes have protective effects on susceptibility to malaria infection . Methods: In present study we investigated the prevalence of TNF [1] -244GgA, TNF [1] - 308 GgA,TNF [1] -238GgA, NOS2-954GgC, MBL54GgA, MBL 57GgA, MBL IVSI - 5 GgA polymorphisms and G6PD variants (Mediterranean, Chatham, Cosenza, A - (202,376) in 315 subjects with G6PD deficiency and 10 malaria patient. All the 315 subjects were selected from five provinces (Fars, Khuzestan, Esfahan, Yazd and Kerman and screened by PCR-RFLP method . Results: The NOS2-954GgA consisted GG(40.31%), GC(53.01%), and CC(6.66% ) where as TNF [1] -308 consisted GG(68.8%), AG(31.11% ) contents. The TNF [1] -244 showed GG(94.60%), AG(5.39%) genotypes and the TNF [1] -238 had GG(92.69% ), AG(6.66%), AA(0.63%) genotypes. The MBL54 polymorphism had GG(75.55%), AG (24.44%), AA(0.63%) genotypes. In MBL 57, had GG(95.23%), AG(4.76%), AA (0.63%) genotypes. The G6PD variants was indicated that Mediterranean mutation in Fars, Khuzestan, Esfahan, Yazd and Kerman provinces was 79.4%, 58%, 83/8%, 64% and 63% respectively and also, the Chatham mutation was 8.8%, 8% 4.5%,3.6% and 0% respectively. Analysis of other four mutations (Cosenza, Arures and A-202 and A-367 ) showed that none of them had those mutations . Conclusion: Our results suggested that genotypes which causes protection against malaria or reduction of risk for celebral malaria and death has the maximum prevalence in samples taken from the five provinces, but in the kolmogorov-smiranov test results, only NOS2-954GgC supported the theory of relation between these polymorphisms and protection against malaria .
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محمدرضا نوری دلویی | mohammad reza noori daloii
department of medical genetic, faculty of medicine, tehran university of medical sciences, pour sina

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا علی وند | mohammad reza alivand
departments of medical genetic, national institute of genetic engineering and biotechnology nigeb , tehran, iran

سازمان اصلی تایید شده: پژوهشگاه ملی مهندسی ژنتیک و زیست فناوری

پریسا عاطف وحید | parisa atef vahid
departments of medical genetic, national institute of genetic engineering and biotechnology nigeb , tehran, iran.

سازمان اصلی تایید شده: پژوهشگاه ملی مهندسی ژنتیک و زیست فناوری

فیض اله هاشمی گرجی | feyzollah hashemi gorji
department of genetics, science and research branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهرداد هاشمی | mehrdad hashemi
departments of molecular genetics, islamic azad university, tehran medical branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-102&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 1
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات