این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Physiology and Pharmacology، جلد ۱۵، شماره ۱، صفحات ۱۱۶-۱۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of pretreatment with non hypotensive dose of ramiprilat and losartan on myocardial ischemia-reperfusion induced arrhythmias and infarct size in rats
چکیده انگلیسی مقاله Introduction: Inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. The aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ACE) inhibitor, ramiprilat and angiotensin type 1 (AT1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat model of ischemia-reperfusion injury. Methods: Seventy male Wistar rats were divided into five groups. One group received saline as control. Other groups were given 10 mg/kg/day of losartan for one (L-1W) or ten weeks (L-10W) as well as 50 μg/kg/day of ramiprilat for one (R-1W) or ten weeks (R-10W) using a feeding needle. The rats were subjected to 30 minutes occlusion and 120 minutes reperfusion of the left coronary artery. Infarct size was determined using triphenyl tetrazolium chloride staining. Ischemia-induced ventricular arrhythmias were analyzed in accordance with the Lambeth conventions. Results: Myocardial infarct size and the number of ventricular beats were significantly reduced in R-1W group, but the reduction was not significant in L-1W. After increasing the duration of pretreatment to 10 weeks in L-10W group, the infarct size, the number of ventricular beats and the episodes of ventricular tachycardia were significantly decreased. However in R-10W group the reduction of ventricular arrhythmias was not significant Conclusion: Based on the above mentioned results it could be concluded that losartan and ramiprilat, at a nonhypotensive dose, can reduce the induction of arrhythmias and infarct size following myocardial ischemia reperfusion. These drugs appear to act in a time-dependent manner. Therefore, we expected an increased cardiac effect by long-term administration of losartan. However prolonged treatment with ramiprilat reduced its protective effect.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فاطمه صفری | fatemeh safari
dept of physiology, faculty of medical sciences, tarbiat modares university, tehran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

سهراب حاجی زاده | sohrab hajizadeh
dept of physiology, faculty of medical sciences, tarbiat modares university, tehran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

شهناز shekarforush | shahnaz shekarforush
islamic azad university, arsanjan branch, fars

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهدی فروزنده | mehdi forouzandeh
dept. medical biotechnology, faculty of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

محسن فوادالدینی | mohsen foadoddini
department of physiology and pharmacology, birjand university of medical sciences, birjand, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بیرجند (Birjand university of medical sciences)

غلامرضا بیات | gholamreza bayat
dept of physiology, faculty of medical sciences, tarbiat modares university, tehran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

بیتا هوشمند | bita houshmand
dept of physiology, faculty of medical sciences, tarbiat modares university, tehran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

علی خوش باطن | ali khoshbaten
exercise physiology research centre, baqiatallah university of medical sciences, tehran
نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-494-1&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cardivascular system
نوع مقاله منتشر شده Original Research
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات