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Physiology and Pharmacology، جلد ۱۲، شماره ۳، صفحات ۱۹۴-۲۰۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Behavioral study of effects of mesenchymal stem cells transplant on motor deficits improvement in animal model of Huntington's disease
چکیده انگلیسی مقاله Introduction: As an inherited neurodegenerative disease, Huntington's disease is accompanied with wide neuronal degeneration in neostriatum and neocortex. Progress of the disease causes disabling clinical effects on movements, recognition and physiology of the body, and finally results in death. At this stage of knowledge we are, there is no effective therapeutic strategy for diminishing the motor disorders of Huntington's disease. In recent years, cellular transplantation has been an effective therapeutic method for neurodegenerative disease. Material and methods: In this paper, the effects of bone marrow derived mesenchymal stem cells were assessed in animal model of Huntington disease. After causing ipsilateral lesion in striatum with Quinolinic acid, bone marrowe derived mesenchymal stem cells which had been isolated and purified from 4-6 weeks old rats, transplanted into damage striatum. The efficiency of cellular transplantation for improvement of motor disorder was assessed by cylinder test and Apomorphin induced rotation tests, during eight weeks after engraftment. Results: Results show significant improvement (p ≤ 0.0001) in motor disorders and striatal atrophy percent. Conclision: According to results of this assay, cell therapy by means of bone marrow derived adult stem cells promises for treatment of neurodegenerative diseases, especially Huntington's disease.
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نویسندگان مقاله محمد امین عدالت منش | mohammad amin edalatmanesh
biotechnology amp;amp; tissue engineering research center, ferdowsi university of mashhad, mashad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

احمدرضا بهرامی | ahmad reza bahrami
institute of biotechnology


مرتضی بهنام رسولی | morteza behnam rasuli
dept. biology, faculty of science, ferdowsi university of mashhad, mashad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

علی مقیمی | ali moghimi
dept. biology, faculty of science, ferdowsi university of mashhad, mashad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

مریم مقدم متین | maryam moghadam matin


فاطمه ناصری | fatemeh naseri
dept. biology, faculty of science, ferdowsi university of mashhad, mashad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-169-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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