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Physiology and Pharmacology، جلد ۱۱، شماره ۳، صفحات ۱۷۴-۱۸۱
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عنوان انگلیسی The role of adenosine A1 receptors on post seizure depression period in rats
چکیده انگلیسی مقاله Epilepsy is among the most common disorders of the central nervous system and there is not an absolute method for its treatment. It has been shown that each seizure has a depressing effect on the following seizure. Thus, finding the mechanisms responsible in this phenomenon can improve our knowledge toward new ways for epilepsy treatment. In this study, the role of adenosine A1 receptors in post seizure depressing period was investigated in amygdala kindling model of epilepsy. Methods: Rats were kindled by daily electrical stimulation of amygdala. At first, different groups of kindled animals were stimulated at different times after the first stimulation and the percent of suppression of seizure parameters were calculated. Then, 8-cyclopenthyl-1, 3-dimethylxanthine (CPT), a selective adenosine A1 receptor antagonist (50 and 200 μM) were intracerebroventricularly microinjected before the second stimulation and its effect on percent of suppression induced by the first stimulation was investigated. Results: In the second stimulation, applied at 10 and 30 min after the first stimulation, the seizure parameters were significantly reduced. CPT microinjection (50 and 200 μM) significantly decreased the percent of suppression of seizure parameters. This decrease was significant at 10 and 30 min after the first stimulation with compare to the groups received the drug solvent. Conclusion: Obtained results showed that endogenous adenosine has a role in post seizure depression period through A1 receptors. As the blocking of A1 receptors by CPT could not completely prevent this period, other factors may also play role in this suppression.
کلیدواژه‌های انگلیسی مقاله Epilepsy, Kindling, Post seizure suppression, Adenosine
نویسندگان مقاله طاهره زینالی | tahereh zeinali
department of biology, faculty of sciences, shaheed bahonar university, kerman

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

جواد میرنجفی زاده | javad mirnajafi zadeh
department of physiology, school of medical sciences, tarbiat modares university, tehran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

وحید شیبانی | vahid sheibani
neuroscience research centre, kerman university of medical sciences, kerman

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

محمد رضا پالیزوان | mohammad eza palizvan
department of physiology, faculty of medicine, arak university of medical sciences, arak

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

مهدی عباس نژاد | mehdi abbasnejad
department of biology, faculty of sciences, shaheed bahonar university, kerman

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

نشانی اینترنتی http://www.phypha.ir/ppj/browse.php?a_code=A-10-51-7&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Nervous system (others)
نوع مقاله منتشر شده Original Research
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