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Research in Pharmaceutical Sciences، جلد ۱۳، شماره ۲، صفحات ۱۶۸-۱۷۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Synthesis and cytotoxic evaluation of some novel quinoxalinedione diarylamide sorafenib analogues
چکیده انگلیسی مقاله A series of novel sorafenib analogues containing a quinoxalinedione ring and amide linker were synthesized. A total of 9 novel compounds in 6 synthetic steps were synthesized. Briefly, the amino group of p-aminophenol was first protected which then followed by O-arylation with 5-chloro-2-nitroaniline to provide compound d . Reduction of the nitro group of compound d and cyclization of the diamine group of compound e with oxalic acid afforded compound f which on deacetylation yeilded compound g . Then compound g was reacted with different acyl halides to afford the target compounds 1h-1p . Chemical structures of synthesized compounds were confirmed by 1 H NMR and FT-IR analysis. All compounds were evaluated at 1, 10, 50 and 100 μM concentrations for their cytotoxicity against HeLa and MCF-7 cancer cell lines. Some of the compounds showed good cytotoxic activity, especially compounds 1i and 1k-1n with the IC 50 values of 19, 16, 22, 18, and 16 µM against MCF-7 cell line and 20, 18, 25, 20, and 18 µM against HeLa cell line, respectively.
کلیدواژه‌های انگلیسی مقاله Cytotoxicity,Sorafenib,Quinoxalinedione,Amide
نویسندگان مقاله | Mojtaba Khandan
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran


| Sedighe Sadeghian Rizi
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran


| Ghadamali Khodarahmi
Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I.R. Iran


| Farshid Hassanzadeh


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1821
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-628571.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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