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Iranian Journal of Parasitology، جلد ۱۳، شماره ۲، صفحات ۱۸۰-۱۸۵
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عنوان انگلیسی Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions
چکیده انگلیسی مقاله Background: This study aimed to investigate the anti- Acanthamoeba effects of the most used marketed disinfecting solutions in Iran. Moreover, the efficacy of some nano-compounds was tested against pathogenic Acanthamoeba . Methods: The present study was conducted in the School of Public Health, Tehran University of Medical sciences, Tehran, Iran during 2015-2016. Cysts of Acanthamoeba T4 genotype (7 x 10 4 /ml) mixed at the equal volume with contact lens solutions including Opti-free, Ginza, ReNu, Maxima, Light, and Cyclean for the recommended time by the manufacturers. Nano-silver and nano-gold compounds were also treated with the amoebae. Chlorhexidine 0.02% and normal saline were used as positive and negative controls, respectively. Dead and alive amoebae were determined using vital stain and suspension was cultured in non-nutrient agar. The entire process was repeated at least three times. Results: In none of the solutions in the manufacturer's brochure recommended time, full cytotoxic effect was observed on the cysts of Acanthamoeba . Opti free express solution destroyed the cysts after 6 days. Nanosilver and nano-gold compounds showed no cytotoxic effect on the cysts of Acanthamoeba . Conclusion: None of the Nanoparticles compounds as well as contact lenses disinfecting solutions which studied was effective on Acanthamoeba cysts in the manufacturer's brochure recommended time. However, continuing study on Nano-silver and Nano-gold compounds to find effective ingredients against Acanthamoeba are highly recommended.
کلیدواژه‌های انگلیسی مقاله Acanthamoeba, Acanthamoeba keratitis, Nanoparticles
نویسندگان مقاله | Maryam NIYYATI
Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Roghayeh SASANI
Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mehdi MOHEBALI
Dept. of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mahmoud GHAZI-KHANSARI
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran


| Faranak KARGAR
Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Elham HAJIALILO
Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mostafa REZAEIAN


نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/2200
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/69/article-69-671373.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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