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Medical Journal of Islamic Republic of Iran، جلد ۲۲، شماره ۲، صفحات ۵۵-۶۲
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عنوان انگلیسی Correlation between urine macrophage migration inhibitory factor (MIF)/creatinine ratio and time after kidney transplantation
چکیده انگلیسی مقاله  Abstract Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of chronic allograft nephropathy suggests that MIF may be an important mediator in the process of chronic allograft nephropathy. Therefore, the aims of this study were to measure urine concentration of MIF after renal transplantation, and to determine if it increases with time. Methods: In this prospective cross-sectional study twenty-two pediatric patients (case, group A) who received kidney transplants between 1999 and 2006, and forty healthy children (control, group B) were recruited. Urine MIF and creatinine were assessed in all patients. Urine MIF concentrations were quantitated by ELISA. Results: The mean ratios of urine MIF/Creatinine (Cr) were calculated as 5.046(SEM=2.04) pg/μmol creatinine in transplanted-kidney patients (group A) and 1.85(SEM=0.35) pg/μmol creatinine in healthy individuals (group B). Agood significant correlation was seen between urine MIF/Cr ratio and time after kidney transplantation in recipients (P=0.002, rSpearman = +0.633). Conclusion: This study shows significant correlation between urine MIF/Cr ratio and time passed after transplantation. Increasing MIF/Cr ratios were seen in patients with a longer post transplantation period. Therefore, it is necessary to determine the role of macrophages in chronic renal nephropathy especially chronic rejection with additive studies and then study the effect of anti-MIF antibodies in the treatment of this condition.
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نویسندگان مقاله حسن اتوکش | hasan otukesh
urology and nephrology research center, labbafi nejad hospital, tehran, iran.

سازمان های دیگر: Urology and Nephrology Research Center,

سید محمد فرشته نژاد | seyed mohammad fereshtehnejad
medical student research committee, iran university of medical sciences and health services,tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

رزیتا حسینی | rozita hoseini
urology and nephrology research center, labbafi nejad hospital, tehran, iran.


مجید چالیان | majid chalian
iran university of medical sciences and health services, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

آرش بدایت | arash bedayat
iran university of medical sciences and health services, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

رضا سلمان یزدی | reza salman yazdi
rooyan institiute, tehran, iran.


امیر ابراهیم صفرزاده | amir ebrahim safarzadeh
iran university of medical sciences and health services, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سعید صباغی | saeed sabaghi
rooyan institiute, tehran, iran.


سعید مهدوی | saeed mahdavi
rooyan institiute, tehran, iran.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-43&slc_lang=en&sid=en
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