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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۲، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Experience of Sorafenib as first line in metastatic Renal Cell Carcinoma in a tertiary care centre.
چکیده انگلیسی مقاله Introduction: Metastatic renal cell carcinoma is chemoresistant and radioresistant disease with poor survival historically but outcome has improved in past decade after introduction of tyrosine kinase inhibitors like sunitinib and sorafenib. Sorafenib was not tested in Indian patients with metastatic RCC till date. Material and methods: This is a single arm, prospective, observational study done in unselected population of 60 patients with metastatic RCC treated with sorafenib as first line therapy to assess efficacy and safety. Results: Twenty three out of 60 patients (38.33%) were continued with sorafenib at the end of study. Overall response rates (ORR), stable disease (SD) and disease control rates (DCR) were 35%, 43.33% and 78.33% respectively. Median progression free survival (PFS) and overall survival (OS) were 6 months and 8 months respectively and associated with histopathology, Memorial Sloan Kettering Cancer Centre (MSKCC) risk groups, Heng risk groups and performance status. Best tolerated dose was 400 mg per day which was half of standard dose. Fatigue, diarrhea, rashes and hand foot syndrome were common side effects while hypertension was rare. Conclusion: Sorafenib is effective and safe in Indian patients with metastatic RCC as first line therapy with poor tolerance to dose more than 400 mg per day. Side effects are mostly manageable.
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نویسندگان مقاله | Dr. Mohit Saxena
DEPARTMENT OF MEDICAL AND PEDIATRIC ONCOLOGY, GCRI, AHMEDABAD, GUJARAT, INDIA.


| Dr. Irappa Madabhavi


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/684
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